Polymorphism observed in dapsone-flavone cocrystals that present pronounced differences in solubility and stability
文献类型：期刊论文
| 作者 | He, Hongyan; Jiang, Linglei; Zhang, Qi; Huang, Ying; Wang, Jian-Rong ; Mei, Xuefeng
|
| 刊名 | CRYSTENGCOMM
 |
| 出版日期 | 2015 |
| 卷号 | 17期号:34页码:6566-6574 |
| ISSN号 | 1466-8033 |
| DOI | 10.1039/c5ce01208b |
| 文献子类 | Article |
| 英文摘要 | Four dapsone-flavone cocrystals were synthesized, including three polymorphic 1 : 1 cocrystals and a 1 : 2 cocrystal. Single crystal structures were disclosed, and the differences in H-bonding interactions were illustrated by comparison of the crystal structures and Hirshfeld surface analysis. The various cocrystals were fully characterized by X-ray powder diffraction, FTIR and thermal analysis. The solubilities, dissolution rates and form transformations in solution were determined. The phase transformation experiments revealed complex phase transformations among the cocrystals. Solid-state transformations among different stoichiometries were also observed in the dapsone-flavone system. |
| WOS关键词 | HIRSHFELD SURFACE-ANALYSIS ; PHARMACEUTICAL COCRYSTALS ; CO-CRYSTALS ; INTERMOLECULAR INTERACTIONS ; DRUG ; STATE ; SOLVATOMORPHISM ; SULFACETAMIDE ; SYNTHONS ; AMIDES |
| 资助项目 | National Natural Science Foundation of China[81273479] ; National Natural Science Foundation of China[81402898] ; Shanghai Institute of Materia Medica New-Star Plan B[00000000] |
| WOS研究方向 | Chemistry ; Crystallography |
| 语种 | 英语 |
| WOS记录号 | WOS:000359951600012 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276710]  |
| 专题 | 药物质量控制与固体化学研究中心 |
| 通讯作者 | He, Hongyan |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Hongyan,Jiang, Linglei,Zhang, Qi,et al. Polymorphism observed in dapsone-flavone cocrystals that present pronounced differences in solubility and stability[J]. CRYSTENGCOMM,2015,17(34):6566-6574. |
| APA | He, Hongyan,Jiang, Linglei,Zhang, Qi,Huang, Ying,Wang, Jian-Rong,&Mei, Xuefeng.(2015).Polymorphism observed in dapsone-flavone cocrystals that present pronounced differences in solubility and stability.CRYSTENGCOMM,17(34),6566-6574. |
| MLA | He, Hongyan,et al."Polymorphism observed in dapsone-flavone cocrystals that present pronounced differences in solubility and stability".CRYSTENGCOMM 17.34(2015):6566-6574. |
入库方式： OAI收割
来源：上海药物研究所
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