中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Absolute configuration of podophyllotoxone and its inhibitory activity against human prostate cancer cells

文献类型:期刊论文

作者Li Juan2,3; Feng Juan2; Luo Cheng4; Sung, Herman Ho-Yung1; Jiang Ren-Wang2,3
刊名CHINESE JOURNAL OF NATURAL MEDICINES
出版日期2015-01
卷号13期号:1页码:59-64
关键词Podophyllotoxone Absolute configuration Prostate cancer Tubulin Molecular docking
ISSN号2095-6975
文献子类Article
英文摘要Podophyllotoxone (1) was isolated from the roots of Dysosma versipellis. The structure was determined by spectroscopic analysis in combination with single-crystal X-ray analysis. The absolute configuration of compound 1 was assigned based on the Flack parameter. It showed significant inhibitory activities against human prostate cancer cells PC3 and DU145 with IC50 values being 14.7 and 20.6 mu mol.L-1, respectively. It also arrested the cells at G2/M phase. Tubulin polymerization assay showed that it inhibited the tubulin polymerization in a dose-dependent manner, and molecular docking analysis revealed a different binding mode with tubulin as compared with those known tubulin inhibitors.
WOS关键词BINDING ; TUBULIN ; APOPTOSIS ; CURCUMIN ; COMPLEX
资助项目Fund of Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization[FPRU2013-4] ; Fund of Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization[ZRJJ2013-4] ; National Natural Science Foundation of China[21072078] ; Fundamental Research Funds for the Central Universities[11609202] ; Guangdong High Level Talent Scheme[00000000]
WOS研究方向Integrative & Complementary Medicine ; Pharmacology & Pharmacy
语种英语
CSCD记录号CSCD:5345283
WOS记录号WOS:000349475400007
出版者CHINESE JOURNAL NATURAL MEDICINES
源URL[http://119.78.100.183/handle/2S10ELR8/276757]  
专题药物发现与设计中心
通讯作者Jiang Ren-Wang
作者单位1.Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China
2.Jinan Univ, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou, Guangdong, Peoples R China;
3.Guangxi Zhuang Autonomous Reg & Chinese Acad Sci, Guangxi Inst Bot, Guangxi Key Lab Funct Phytochem Res & Utilizat, Guilin 541006, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab New Drug Res, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714
Li Juan,Feng Juan,Luo Cheng,et al. Absolute configuration of podophyllotoxone and its inhibitory activity against human prostate cancer cells[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2015,13(1):59-64.
APA Li Juan,Feng Juan,Luo Cheng,Sung, Herman Ho-Yung,&Jiang Ren-Wang.(2015).Absolute configuration of podophyllotoxone and its inhibitory activity against human prostate cancer cells.CHINESE JOURNAL OF NATURAL MEDICINES,13(1),59-64.
MLA Li Juan,et al."Absolute configuration of podophyllotoxone and its inhibitory activity against human prostate cancer cells".CHINESE JOURNAL OF NATURAL MEDICINES 13.1(2015):59-64.

入库方式: OAI收割

来源:上海药物研究所

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