Absolute configuration of podophyllotoxone and its inhibitory activity against human prostate cancer cells
文献类型：期刊论文
| 作者 | Li Juan2,3; Feng Juan2; Luo Cheng4 ; Sung, Herman Ho-Yung1; Jiang Ren-Wang2,3
|
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2015-01 |
| 卷号 | 13期号:1页码:59-64 |
| 关键词 | Podophyllotoxone Absolute configuration Prostate cancer Tubulin Molecular docking |
| ISSN号 | 2095-6975 |
| 文献子类 | Article |
| 英文摘要 | Podophyllotoxone (1) was isolated from the roots of Dysosma versipellis. The structure was determined by spectroscopic analysis in combination with single-crystal X-ray analysis. The absolute configuration of compound 1 was assigned based on the Flack parameter. It showed significant inhibitory activities against human prostate cancer cells PC3 and DU145 with IC50 values being 14.7 and 20.6 mu mol.L-1, respectively. It also arrested the cells at G2/M phase. Tubulin polymerization assay showed that it inhibited the tubulin polymerization in a dose-dependent manner, and molecular docking analysis revealed a different binding mode with tubulin as compared with those known tubulin inhibitors. |
| WOS关键词 | BINDING ; TUBULIN ; APOPTOSIS ; CURCUMIN ; COMPLEX |
| 资助项目 | Fund of Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization[FPRU2013-4] ; Fund of Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization[ZRJJ2013-4] ; National Natural Science Foundation of China[21072078] ; Fundamental Research Funds for the Central Universities[11609202] ; Guangdong High Level Talent Scheme[00000000] |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5345283 |
| WOS记录号 | WOS:000349475400007 |
| 出版者 | CHINESE JOURNAL NATURAL MEDICINES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276757]  |
| 专题 | 药物发现与设计中心 |
| 通讯作者 | Jiang Ren-Wang |
| 作者单位 | 1.Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China 2.Jinan Univ, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou, Guangdong, Peoples R China; 3.Guangxi Zhuang Autonomous Reg & Chinese Acad Sci, Guangxi Inst Bot, Guangxi Key Lab Funct Phytochem Res & Utilizat, Guilin 541006, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab New Drug Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li Juan,Feng Juan,Luo Cheng,et al. Absolute configuration of podophyllotoxone and its inhibitory activity against human prostate cancer cells[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2015,13(1):59-64. |
| APA | Li Juan,Feng Juan,Luo Cheng,Sung, Herman Ho-Yung,&Jiang Ren-Wang.(2015).Absolute configuration of podophyllotoxone and its inhibitory activity against human prostate cancer cells.CHINESE JOURNAL OF NATURAL MEDICINES,13(1),59-64. |
| MLA | Li Juan,et al."Absolute configuration of podophyllotoxone and its inhibitory activity against human prostate cancer cells".CHINESE JOURNAL OF NATURAL MEDICINES 13.1(2015):59-64. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。