Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum Sampsonii
文献类型：期刊论文
| 作者 | Zhu, Hucheng3; Chen, Chunmei3; Yang, Jing2,4; Li, Xiao-Nian2; Liu, Junjun3; Sun, Bin3; Huang, Sheng-Xiong2; Li, Dongyan1; Yao, Guangmin3; Luo, Zengwei3 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2014-12-19 |
| 卷号 | 16期号:24页码:6322-6325 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol5030579 |
| 文献子类 | Article |
| 英文摘要 | Hyperisampsins AD (1-4), with tetracyclo[6.3.1.1(3,10).0(3,7)]tridecane skeletons and seven biogenetically related congeners (5=11), were isolated from Hypericum sampsonii. Their structures were elucidated by comprehensive spectroscopic techniques. The absolute configuration of 1 was established by ECD calculations, and those of 5 and 9 were confirmed by single X-ray crystallographic analyses. Hyperisampsins A and D showed potent anti-HIV activities with EC50 of 2.97 and 0.97 mu M and selectivity index of 4.80 and 7.70, respectively. |
| WOS关键词 | POLYCYCLIC POLYPRENYLATED ACYLPHLOROGLUCINOLS ; PRENYLATED BENZOPHENONE ; BENZOYLPHLOROGLUCINOL DERIVATIVES ; HYPERFORIN ; CHEMISTRY ; PLUKENETIONE ; XANTHONES ; LEAVES |
| 资助项目 | Program for New Century Excellent Talents in University, State Education Ministry of China[NCET-2008-0224] ; National Natural Science Foundation of China[31370372] ; National Natural Science Foundation of China[31200258] ; National Natural Science Foundation of China[81202423] ; National Science and Technology Project of China[2011ZX09102-004] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000346759900015 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276797]  |
| 专题 | 药物发现与设计中心 |
| 通讯作者 | Xue, Yongbo |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China; 3.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhu, Hucheng,Chen, Chunmei,Yang, Jing,et al. Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum Sampsonii[J]. ORGANIC LETTERS,2014,16(24):6322-6325. |
| APA | Zhu, Hucheng.,Chen, Chunmei.,Yang, Jing.,Li, Xiao-Nian.,Liu, Junjun.,...&Zhang, Yonghui.(2014).Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum Sampsonii.ORGANIC LETTERS,16(24),6322-6325. |
| MLA | Zhu, Hucheng,et al."Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum Sampsonii".ORGANIC LETTERS 16.24(2014):6322-6325. |
入库方式： OAI收割
来源：上海药物研究所
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