Preparation and Solid-State Characterization of Dapsone Drug-Drug Co-Crystals
文献类型：期刊论文
| 作者 | Jiang, Linglei; Huang, Ying; Zhang, Qi; He, Hongyan; Xu, Yun; Mei, Xuefeng
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| 刊名 | CRYSTAL GROWTH & DESIGN
 |
| 出版日期 | 2014-09 |
| 卷号 | 14期号:9页码:4562-4573 |
| ISSN号 | 1528-7483 |
| DOI | 10.1021/cg500668a |
| 文献子类 | Article |
| 英文摘要 | Pharmaceutical co-crystals involving two active pharmaceutical ingredients are rarely revealed in the literature. In this work, crystal engineering principles were exercised to guide the design and synthesis of the Biopharmaceutics Classification System class W drug dapsone (DAP). We reported six drug drug co-crystals of DAP with sulfanilamide, flavone, luteolin, caffeine in 1:1 stoichiometry, caffeine in 1:2 stoichiometry, and 2(3H)-benzothiazolone. Bioactive coformers were deliberately selected. The resulting co-crystals were fully characterized by a range of analytical technologies, including X-ray powder diffraction, Fourier transform infrared spectroscopy, polarized light microscopy, differential scanning calorimetry, and thermogravimetric analysis, etc. Single-crystal structure analysis reveals that reoccurring supramolecular synthons are observed in different DAP co-crystals. Equilibrium solubility and intrinsic dissolution rates were also compared with those of the parent drug. This work expands the pharmaceutically acceptable solid forms of DAP and supplements the successful cases of drug drug co-crystals. |
| WOS关键词 | PHARMACEUTICAL COCRYSTALS ; SOLUBILITY ADVANTAGE ; SHORT HISTORY ; DERIVATIVES ; ACID ; BIOAVAILABILITY ; FLAVONOIDS ; COMPLEXES ; COMPOUND ; MODEL |
| 资助项目 | National Natural Science Foundation of China[81273479) and Chinese Academy of Science for funding.] ; Chinese Academy of Science[00000000] |
| WOS研究方向 | Chemistry ; Crystallography ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000341226500040 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276921]  |
| 专题 | 药物质量控制与固体化学研究中心 |
| 通讯作者 | Mei, Xuefeng |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Linglei,Huang, Ying,Zhang, Qi,et al. Preparation and Solid-State Characterization of Dapsone Drug-Drug Co-Crystals[J]. CRYSTAL GROWTH & DESIGN,2014,14(9):4562-4573. |
| APA | Jiang, Linglei,Huang, Ying,Zhang, Qi,He, Hongyan,Xu, Yun,&Mei, Xuefeng.(2014).Preparation and Solid-State Characterization of Dapsone Drug-Drug Co-Crystals.CRYSTAL GROWTH & DESIGN,14(9),4562-4573. |
| MLA | Jiang, Linglei,et al."Preparation and Solid-State Characterization of Dapsone Drug-Drug Co-Crystals".CRYSTAL GROWTH & DESIGN 14.9(2014):4562-4573. |
入库方式： OAI收割
来源：上海药物研究所
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