Supramolecular structures and physicochemical properties of norfloxacin salts
文献类型：期刊论文
| 作者 | Xu, Yun; Jiang, Linglei; Mei, Xuefeng
|
| 刊名 | ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS
 |
| 出版日期 | 2014-08 |
| 卷号 | 70页码:750-760 |
| ISSN号 | 0108-7681 |
| DOI | 10.1107/S2052520614011718 |
| 文献子类 | Article |
| 英文摘要 | Seven new molecular salts of norfloxacin (1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1H-quinoline-3-carboxylic acid; abbreviated as NF) with various organic acids (adipic acid, mucic acid, o-OH-benzoic acid, m-OH-benzoic acid, p-OH-benzoic acid, naphthalene-1, 5-disulfonic acid and naphthalene-2-sulfonic acid) were synthesized and their crystal structures were determined by X-ray crystallography. Supramolecular structures and reccurring packing patterns are discussed to understand the influence of non-covalent interactions in determination of the crystal packing and hydrate inclusion. The formation of hydrates was commonly observed among various NF salts, except for the adipate salt which exists as an anhydrous form. The physicochemical properties of salts were fully characterized with a variety of analytical techniques, including powder X-ray diffraction (PXRD), Fourier transform IR (FT-IR), Raman spectroscopy, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), hot-stage microscopy (HSM) and dynamic vapour sorption (DVS) etc. The synthesized norfloxacin salts were found to have different physicochemical properties, superior solubility and hygroscopicity. Particularly, NF adipate was found to be a desirable candidate for further development. |
| WOS关键词 | SOLID-STATE ; PHARMACEUTICAL COCRYSTAL ; CO-CRYSTAL ; DRUGS ; FLUOROQUINOLONES ; POLYMORPHISM ; DISCOVERY ; SELECTION |
| 资助项目 | National Natural Science Foundation of China[81273479] ; Chinese Academy of Science[00000000] |
| WOS研究方向 | Chemistry ; Crystallography |
| 语种 | 英语 |
| WOS记录号 | WOS:000342897300013 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276950]  |
| 专题 | 药物质量控制与固体化学研究中心 |
| 通讯作者 | Mei, Xuefeng |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Yun,Jiang, Linglei,Mei, Xuefeng. Supramolecular structures and physicochemical properties of norfloxacin salts[J]. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS,2014,70:750-760. |
| APA | Xu, Yun,Jiang, Linglei,&Mei, Xuefeng.(2014).Supramolecular structures and physicochemical properties of norfloxacin salts.ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS,70,750-760. |
| MLA | Xu, Yun,et al."Supramolecular structures and physicochemical properties of norfloxacin salts".ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS 70(2014):750-760. |
入库方式： OAI收割
来源：上海药物研究所
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