中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Supramolecular structures and physicochemical properties of norfloxacin salts

文献类型:期刊论文

作者Xu, Yun; Jiang, Linglei; Mei, Xuefeng
刊名ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS
出版日期2014-08
卷号70页码:750-760
ISSN号0108-7681
DOI10.1107/S2052520614011718
文献子类Article
英文摘要Seven new molecular salts of norfloxacin (1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1H-quinoline-3-carboxylic acid; abbreviated as NF) with various organic acids (adipic acid, mucic acid, o-OH-benzoic acid, m-OH-benzoic acid, p-OH-benzoic acid, naphthalene-1, 5-disulfonic acid and naphthalene-2-sulfonic acid) were synthesized and their crystal structures were determined by X-ray crystallography. Supramolecular structures and reccurring packing patterns are discussed to understand the influence of non-covalent interactions in determination of the crystal packing and hydrate inclusion. The formation of hydrates was commonly observed among various NF salts, except for the adipate salt which exists as an anhydrous form. The physicochemical properties of salts were fully characterized with a variety of analytical techniques, including powder X-ray diffraction (PXRD), Fourier transform IR (FT-IR), Raman spectroscopy, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), hot-stage microscopy (HSM) and dynamic vapour sorption (DVS) etc. The synthesized norfloxacin salts were found to have different physicochemical properties, superior solubility and hygroscopicity. Particularly, NF adipate was found to be a desirable candidate for further development.
WOS关键词SOLID-STATE ; PHARMACEUTICAL COCRYSTAL ; CO-CRYSTAL ; DRUGS ; FLUOROQUINOLONES ; POLYMORPHISM ; DISCOVERY ; SELECTION
资助项目National Natural Science Foundation of China[81273479] ; Chinese Academy of Science[00000000]
WOS研究方向Chemistry ; Crystallography
语种英语
WOS记录号WOS:000342897300013
出版者WILEY-BLACKWELL
源URL[http://119.78.100.183/handle/2S10ELR8/276950]  
专题药物质量控制与固体化学研究中心
通讯作者Mei, Xuefeng
作者单位Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Xu, Yun,Jiang, Linglei,Mei, Xuefeng. Supramolecular structures and physicochemical properties of norfloxacin salts[J]. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS,2014,70:750-760.
APA Xu, Yun,Jiang, Linglei,&Mei, Xuefeng.(2014).Supramolecular structures and physicochemical properties of norfloxacin salts.ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS,70,750-760.
MLA Xu, Yun,et al."Supramolecular structures and physicochemical properties of norfloxacin salts".ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS 70(2014):750-760.

入库方式: OAI收割

来源:上海药物研究所

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