Novel chlorantraniliprole derivatives as potential insecticides and probe to chlorantraniliprole binding site on ryanodine receptor
文献类型：期刊论文
| 作者 | Luo, Min2; Chen, Qichao2; Wang, Jin2; Hu, Changyan2; Lu, Jing1; Luo, Xiaomin1 ; Sun, Dequn2
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2014-04-15 |
| 卷号 | 24期号:8页码:1987-1992 |
| 关键词 | Chlorantraniliprole derivatives Insecticidal activities Molecular docking Ryanodine receptor Binding site |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2014.02.053 |
| 文献子类 | Article |
| 英文摘要 | The lepidopteran pests such as diamondback moth are the regularly harmful pests of crops in the world, which brings enormous losses in crop production. Chlorantraniliprole is an anthranilic diamide insecticide registered for the control of lepidopteran pests with high insecticidal activity, however with uncertain binding site action target of chlorantraniliprole on ryanodine receptor, a series of new chlorantraniliprole derivatives were synthesized and the insecticidal activities of these compounds against diamondback moth were evaluated with chlorantraniliprole and indoxacarb as control. All compounds except 8h, 8p and 8t exhibited varying degree of activities against diamondback moth. Especially, compounds 8c, 8i, 8k and 8l displayed good insecticidal activities against diamondback moth and the activities are even better than that of indoxacarb during 72 h period. The K-i values of all synthesized compounds were calculated through autodocking program respectively. The relationship between calculation value of molecular docking and results of insecticidal activities indicated that the proposed specific receptor, the membrane-spanning domain protein of diamondback moth ryanodine receptor in our study might have chlorantraniliprole binding sites. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | ANTHRANILIC DIAMIDES ; PLUTELLA-XYLOSTELLA ; FLUBENDIAMIDE ; RESISTANCE ; DESIGN |
| 资助项目 | National High-Tech Program of China[2012AA020306] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000333579500024 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277115]  |
| 专题 | 药物安全性评价中心 药物发现与设计中心 |
| 通讯作者 | Sun, Dequn |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Beijing 100864, Peoples R China 2.Shandong Univ Weihai, Marine Coll, Weihai 264209, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Luo, Min,Chen, Qichao,Wang, Jin,et al. Novel chlorantraniliprole derivatives as potential insecticides and probe to chlorantraniliprole binding site on ryanodine receptor[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(8):1987-1992. |
| APA | Luo, Min.,Chen, Qichao.,Wang, Jin.,Hu, Changyan.,Lu, Jing.,...&Sun, Dequn.(2014).Novel chlorantraniliprole derivatives as potential insecticides and probe to chlorantraniliprole binding site on ryanodine receptor.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(8),1987-1992. |
| MLA | Luo, Min,et al."Novel chlorantraniliprole derivatives as potential insecticides and probe to chlorantraniliprole binding site on ryanodine receptor".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.8(2014):1987-1992. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。