Determination of pK(a) values of a triptolide derivative and its impurities by pressure-assisted capillary electrophoresis
文献类型：期刊论文
| 作者 | Wang, Jian-Ling; Xu, Xue-Jiao; Chen, Dong-Ying
|
| 刊名 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
 |
| 出版日期 | 2014-01-25 |
| 卷号 | 88页码:22-26 |
| 关键词 | Capillary electrophoresis External pressure pK(a) Triptolide derivative Impurities Potentiometric titration |
| ISSN号 | 0731-7085 |
| DOI | 10.1016/j.jpba.2013.08.012 |
| 文献子类 | Article |
| 英文摘要 | A pressure-assisted capillary zone electrophoresis method was developed to determine the pK(a) values of a triptolide derivative (LLDT-246) and its impurities. The method was performed in an uncoated fused-silica capillary under the electric voltage of 18 kV and 50 mbar of external pressure applied simultaneously. A series of running electrolyte buffers were used with pH ranging between 2.2 and 10.0 with the constant ionic strength of 0.05 M. The values of pK(a) of LLDT-246 and two impurities were calculated based on the pH dependence of effective mobilities (mu(eff)). The pK(a) value of LLDT-246 was in good agreement with that of determined by potentiometric titration method. (C) 2013 Elsevier B.V. All rights reserved. |
| WOS关键词 | WATER-INSOLUBLE COMPOUNDS ; PH-METRIC LOG ; ZONE-ELECTROPHORESIS ; DISSOCIATION-CONSTANTS ; PHOSPHINIC PSEUDOPEPTIDES ; WEAK ELECTROLYTES ; ACIDITY CONSTANTS ; AMINO-ACIDS ; MOBILITIES ; PKA |
| 资助项目 | "Key New Drug Creation and Manufacturing Program", National Science & Technology Major Project of China[2012ZX09301001-001] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000329532800004 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277220]  |
| 专题 | 药物质量控制与固体化学研究中心 |
| 通讯作者 | Chen, Dong-Ying |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Lab Pharmaceut Anal, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jian-Ling,Xu, Xue-Jiao,Chen, Dong-Ying. Determination of pK(a) values of a triptolide derivative and its impurities by pressure-assisted capillary electrophoresis[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2014,88:22-26. |
| APA | Wang, Jian-Ling,Xu, Xue-Jiao,&Chen, Dong-Ying.(2014).Determination of pK(a) values of a triptolide derivative and its impurities by pressure-assisted capillary electrophoresis.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,88,22-26. |
| MLA | Wang, Jian-Ling,et al."Determination of pK(a) values of a triptolide derivative and its impurities by pressure-assisted capillary electrophoresis".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 88(2014):22-26. |
入库方式： OAI收割
来源：上海药物研究所
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