Isostructurality in six celecoxib co-crystals introduced by solvent inclusion
文献类型：期刊论文
| 作者 | Wang, Xiaojuan1,2; Zhang, Qi2; Jiang, Linglei2; Xu, Yun2; Mei, Xuefeng2
|
| 刊名 | CRYSTENGCOMM
 |
| 出版日期 | 2014 |
| 卷号 | 16期号:48页码:10959-10968 |
| ISSN号 | 1466-8033 |
| DOI | 10.1039/c4ce01854k |
| 文献子类 | Article |
| 英文摘要 | Three co-crystals of celecoxib (CEL) and bipyridine derivatives were synthesized based on the synthon design approach and structurally characterized. The resulting two-component complexes have different unit cell parameters and noticeably different packing patterns. Surprisingly, when different organic solvents are introduced into the binary-host crystal systems, six isostructural three-component crystals are obtained. These isomorphic complexes are formed by CEL with two different sets of bipyridine co-formers containing various solvent molecules. A robust H-bonding framework between CEL dimer molecules is found to tolerate subtle changes in the structures of the co-formers and guest solvent molecules. The physicochemical properties of these isomorphic co-crystals are fully examined and compared with their corresponding non-solvate forms. The desolvation mechanism and relative thermodynamic stabilities are also discussed. |
| WOS关键词 | CARBOXYLIC-ACIDS ; COCRYSTALS ; FORMS ; POLYMORPHISM ; DESOLVATION ; SOLUBILITY ; INHIBITOR ; PHARMACOKINETICS ; DISSOLUTION ; DRUG |
| 资助项目 | National Natural Science Foundation of China[81273479] ; National Natural Science Foundation of China[81402898] ; Shanghai Institute of Materia Medica New-Star Plan B[00000000] |
| WOS研究方向 | Chemistry ; Crystallography |
| 语种 | 英语 |
| WOS记录号 | WOS:000345305800005 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277254]  |
| 专题 | 药物质量控制与固体化学研究中心 |
| 通讯作者 | Wang, Xiaojuan |
| 作者单位 | 1.Nanchang Univ, Coll Pharm, Nanchang 330006, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xiaojuan,Zhang, Qi,Jiang, Linglei,et al. Isostructurality in six celecoxib co-crystals introduced by solvent inclusion[J]. CRYSTENGCOMM,2014,16(48):10959-10968. |
| APA | Wang, Xiaojuan,Zhang, Qi,Jiang, Linglei,Xu, Yun,&Mei, Xuefeng.(2014).Isostructurality in six celecoxib co-crystals introduced by solvent inclusion.CRYSTENGCOMM,16(48),10959-10968. |
| MLA | Wang, Xiaojuan,et al."Isostructurality in six celecoxib co-crystals introduced by solvent inclusion".CRYSTENGCOMM 16.48(2014):10959-10968. |
入库方式： OAI收割
来源：上海药物研究所
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