Polymorphism and isomorphism of Huperzine A solvates: structure, properties and form transformation
文献类型：期刊论文
| 作者 | Zhang, Qi; Lu, Liye; Dai, Wenjuan; Mei, Xuefeng
|
| 刊名 | CRYSTENGCOMM
 |
| 出版日期 | 2014 |
| 卷号 | 16期号:10页码:1919-1926 |
| ISSN号 | 1466-8033 |
| DOI | 10.1039/c3ce41965g |
| 文献子类 | Article |
| 英文摘要 | Huperzine A is a naturally occurring alkaloid used in clinical treatments for Alzheimer disease. The drug has also been widely used in dietary supplements for improving memory loss and mental impairment. There are three polymorphs and a monohydrate form reported in the literature. In present work, single crystal structures of a new polymorphic monohydrate and four organic solvates were described. The study of single crystal structures of solvates was used as an example to illustrate the formation of different, yet reoccurring packing patterns depending on the inclusion solvent structures. The physicochemical properties of each solvate were examined by a variety of analytical techniques, including PXRD, Raman, IR, DSC, TGA and DVS etc. Form transformation between solvates and hydrates and desolvation processes were studied by DVS isotherms and slurry experiments. The packing efficiency of various solid-state forms, including three pure polymorphs and six solvates crystals were also compared and the results were correlated with their thermo stabilities. |
| WOS关键词 | SOLID-STATE FORMS ; CRYSTAL-STRUCTURES ; PHYSICOCHEMICAL PROPERTIES ; DESOLVATION KINETICS ; DEHYDRATION KINETICS ; MEDICINAL COMPOUNDS ; SIZE-REDUCTION ; HYDROCHLORIDE ; MONOHYDRATE ; SULFATHIAZOLE |
| WOS研究方向 | Chemistry ; Crystallography |
| 语种 | 英语 |
| WOS记录号 | WOS:000331176000009 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277309]  |
| 专题 | 药物质量控制与固体化学研究中心 药物安全性评价中心 |
| 通讯作者 | Zhang, Qi |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Qi,Lu, Liye,Dai, Wenjuan,et al. Polymorphism and isomorphism of Huperzine A solvates: structure, properties and form transformation[J]. CRYSTENGCOMM,2014,16(10):1919-1926. |
| APA | Zhang, Qi,Lu, Liye,Dai, Wenjuan,&Mei, Xuefeng.(2014).Polymorphism and isomorphism of Huperzine A solvates: structure, properties and form transformation.CRYSTENGCOMM,16(10),1919-1926. |
| MLA | Zhang, Qi,et al."Polymorphism and isomorphism of Huperzine A solvates: structure, properties and form transformation".CRYSTENGCOMM 16.10(2014):1919-1926. |
入库方式： OAI收割
来源：上海药物研究所
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