Highly Crystalline Forms of Valsartan with Superior Physicochemical Stability
文献类型：期刊论文
| 作者 | Wang, Jian-Rong ; Wang, Xiaojuan; Lu, Liye; Mei, Xuefeng
|
| 刊名 | CRYSTAL GROWTH & DESIGN
 |
| 出版日期 | 2013-07 |
| 卷号 | 13期号:7页码:3261-3269 |
| ISSN号 | 1528-7483 |
| DOI | 10.1021/cg400762w |
| 文献子类 | Article |
| 英文摘要 | Single crystal structures of blockbuster antihypertensive drug Valsartan are revealed the first time in this report. Two new highly crystalline forms, named form E and an ethanol solvate form F, were discovered and fully characterized by PXRD, Raman, IR, TG, DSC, and DVS. Conformational flexibility and single crystal structures are discussed in detail. Physicochemical properties, such as hygroscopicity, chemical stability, crystallinity, and dissolution behaviors, are compared with the marketed solid-state form (amorphous state). The results show that the newly discovered highly crystalline form E presents a remarkably different dissolution behavior and superior chemical stability. |
| WOS关键词 | PHARMACEUTICAL SOLID POLYMORPHISM ; HYDROXYPROPYL-BETA-CYCLODEXTRIN ; DRUG APPLICATIONS ; DISSOLUTION ; IMPROVEMENT ; DISPERSION ; PHARMACOKINETICS ; BIOAVAILABILITY ; SOLUBILITY |
| 资助项目 | National Natural Science Foundation of China[81273479] ; Chinese Academy of Sciences[00000000] |
| WOS研究方向 | Chemistry ; Crystallography ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000321542900066 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277546]  |
| 专题 | 药物质量控制与固体化学研究中心 |
| 通讯作者 | Mei, Xuefeng |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jian-Rong,Wang, Xiaojuan,Lu, Liye,et al. Highly Crystalline Forms of Valsartan with Superior Physicochemical Stability[J]. CRYSTAL GROWTH & DESIGN,2013,13(7):3261-3269. |
| APA | Wang, Jian-Rong,Wang, Xiaojuan,Lu, Liye,&Mei, Xuefeng.(2013).Highly Crystalline Forms of Valsartan with Superior Physicochemical Stability.CRYSTAL GROWTH & DESIGN,13(7),3261-3269. |
| MLA | Wang, Jian-Rong,et al."Highly Crystalline Forms of Valsartan with Superior Physicochemical Stability".CRYSTAL GROWTH & DESIGN 13.7(2013):3261-3269. |
入库方式： OAI收割
来源：上海药物研究所
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