New Polymorphs of Huperzine A: Preparation, Structures, and Physicochemical Properties of Anhydrous Crystal Forms
文献类型：期刊论文
| 作者 | Zhang, Qi; Lu, Liye; Dai, Wenjuan; Mei, Xuefeng
|
| 刊名 | CRYSTAL GROWTH & DESIGN
 |
| 出版日期 | 2013-05 |
| 卷号 | 13期号:5页码:2198-2207 |
| ISSN号 | 1528-7483 |
| DOI | 10.1021/cg400313a |
| 文献子类 | Article |
| 英文摘要 | Three new polymorphs (forms I, II, and III) of natural cholinesterase inhibitor Huperzine A were discovered through a comprehensive polymorph screening experiment. Their structures were elucidated by single crystal structure analysis and characterized by powder X-ray diffraction, Fourier transform-infrared spectroscopy, and DXR Raman microscope. The physicochemical properties of these new forms were investigated by thermal analysis (TGA and DSC) and dynamic vapor sorption (DVS) isotherms. The powder dissolution rates were compared with the marketed monohydrate form. Thermodynamic stability, phase transformation, E-T diagram, and drugability properties are also discussed in detail. |
| WOS关键词 | PHARMACEUTICAL SOLID POLYMORPHISM ; SELECTIVE CRYSTALLIZATION ; ALZHEIMERS-DISEASE ; DRUG APPLICATIONS ; TABLETS ; SPECTROSCOPY ; INSIGHTS ; SYSTEM |
| 资助项目 | National Natural Science Foundation of China[81273479] ; Chinese Academy of Science[00000000] |
| WOS研究方向 | Chemistry ; Crystallography ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000318468400049 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277636]  |
| 专题 | 药物质量控制与固体化学研究中心 药物安全性评价中心 |
| 通讯作者 | Mei, Xuefeng |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Qi,Lu, Liye,Dai, Wenjuan,et al. New Polymorphs of Huperzine A: Preparation, Structures, and Physicochemical Properties of Anhydrous Crystal Forms[J]. CRYSTAL GROWTH & DESIGN,2013,13(5):2198-2207. |
| APA | Zhang, Qi,Lu, Liye,Dai, Wenjuan,&Mei, Xuefeng.(2013).New Polymorphs of Huperzine A: Preparation, Structures, and Physicochemical Properties of Anhydrous Crystal Forms.CRYSTAL GROWTH & DESIGN,13(5),2198-2207. |
| MLA | Zhang, Qi,et al."New Polymorphs of Huperzine A: Preparation, Structures, and Physicochemical Properties of Anhydrous Crystal Forms".CRYSTAL GROWTH & DESIGN 13.5(2013):2198-2207. |
入库方式： OAI收割
来源：上海药物研究所
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