Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90
文献类型：期刊论文
| 作者 | Li, Jian3; Sun, Lihua3; Xu, Chunyan3; Yu, Feng3; Zhou, Huan3; Zhao, Yanlong4,5; Zhang, Jian4,5; Cai, Jianhua1; Mao, Cheney1; Tang, Lin3 |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2012-04 |
| 卷号 | 44期号:4页码:300-306 |
| 关键词 | human Hsp90 N-terminal domain ATP hydrolysis catalytic mechanism |
| ISSN号 | 1672-9145 |
| DOI | 10.1093/abbs/gms001 |
| 文献子类 | Article |
| 英文摘要 | The activation of molecular chaperone heat-shock protein 90 (Hsp90) is dependent on ATP binding and hydrolysis, which occurs in the N-terminal domains of protein. Here, we have determined three crystal structures of the N-terminal domain of human Hsp90 in native and in complex with ATP and ATP analog, providing a clear view of the catalytic mechanism of ATP hydrolysis by Hsp90. Additionally, the binding of ATP leads the N-terminal domains to be an intermediate state that could be used to partially explain why the isolated N-terminal domain of Hsp90 has very weak ATP hydrolytic activity. |
| WOS关键词 | HSP90 MOLECULAR CHAPERONE ; CRYSTAL-STRUCTURE ; DNA GYRASE ; BINDING ; COMPLEX ; INHIBITORS ; DOMAIN ; GRP94 ; CYCLE ; PART |
| 资助项目 | National Program on Key Basic Research Project[2011CB911102] ; Shanghai Institute of Applied Physics, Chinese Academy of Sciences[O95501C061] ; Important National Science & Technology Specific Projects[2010ZX09401-401] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4498946 |
| WOS记录号 | WOS:000302297500003 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278136]  |
| 专题 | 药物发现与设计中心 |
| 通讯作者 | He, Jianhua |
| 作者单位 | 1.Vivabiotech Shanghai Ltd, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201204, Peoples R China; 4.Shanghai Jiao Tong Univ, Sch Med, Dept Pathophysiol, Shanghai 200025, Peoples R China; 5.Shanghai Jiao Tong Univ, Sch Med, Chinese Minist Educ, Key Lab Cell Differentiat & Apoptosis, Shanghai 200025, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Jian,Sun, Lihua,Xu, Chunyan,et al. Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2012,44(4):300-306. |
| APA | Li, Jian.,Sun, Lihua.,Xu, Chunyan.,Yu, Feng.,Zhou, Huan.,...&He, Jianhua.(2012).Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,44(4),300-306. |
| MLA | Li, Jian,et al."Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 44.4(2012):300-306. |
入库方式： OAI收割
来源：上海药物研究所
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