Application of Phase Optimized Liquid Chromatography for Related Substances Detection in New Drug Candidate of Tripterygiumforrestii Derivative
文献类型：期刊论文
| 作者 | Lu Jing; Xiang Li-Li; Ji Min; Chen Dong-Ying
|
| 刊名 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2011-08 |
| 卷号 | 39期号:8页码:1266-1269 |
| 关键词 | Phase optimization Liquid chromatography Pharmaceutical Related substances Tripterygiumforrestii derivative |
| ISSN号 | 0253-3820 |
| DOI | 10.3724/SP.J.1096.2011.01266 |
| 文献子类 | Article |
| 英文摘要 | Phase optimized liquid chromatography (POPLC) was applied for the related substance detection in new drug candidate of T8, one of tripterygiumforrestii derivative. Five column segments with different kind of stationary phases were individually employed to perform basic measurements for mixture solutions of T8 and its related substances. The mobile phase was composed of acetonitrile and water (35:65, V/V) with the flow rate of 0. 5 mL/min. The column temperature was set at 30 degrees C and the detection was performed at 219 nm. The dead time of the segment columns was determined using a 0. 05% (m/V) solution of uracil. The retention times and the theoretical plate numbers of T8 and its six known related substances were obtained from the basic measurements. An optimal stationary phase composition of 100 mm total length with 20 mm cyanopropyl silica (CN column) coupled to 80 mm embedded polar octadecyl silica (EPS column) was calculated by the optimizer software. Good separation was obtained in 10 min for the related substance detection in T8 and its forced degraded solutions, as well. |
| WOS关键词 | COLUMNS |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4270701 |
| WOS记录号 | WOS:000296599800027 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278451]  |
| 专题 | 药物质量控制与固体化学研究中心 药物安全性评价中心 |
| 通讯作者 | Chen Dong-Ying |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu Jing,Xiang Li-Li,Ji Min,et al. Application of Phase Optimized Liquid Chromatography for Related Substances Detection in New Drug Candidate of Tripterygiumforrestii Derivative[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2011,39(8):1266-1269. |
| APA | Lu Jing,Xiang Li-Li,Ji Min,&Chen Dong-Ying.(2011).Application of Phase Optimized Liquid Chromatography for Related Substances Detection in New Drug Candidate of Tripterygiumforrestii Derivative.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,39(8),1266-1269. |
| MLA | Lu Jing,et al."Application of Phase Optimized Liquid Chromatography for Related Substances Detection in New Drug Candidate of Tripterygiumforrestii Derivative".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 39.8(2011):1266-1269. |
入库方式： OAI收割
来源：上海药物研究所
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