Solid-state characterization and solubility enhancement of apremilast drug-drug cocrystals
文献类型：期刊论文
| 作者 | Wang, Feng-Yuan1,2; Zhang, Qi2; Zhang, Zaiyong2; Gong, Xiaoyi2; Wang, Jian-Rong2 ; Mei, Xuefeng2
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| 刊名 | CRYSTENGCOMM
 |
| 出版日期 | 2018-10-21 |
| 卷号 | 20期号:39页码:5945-5948 |
| ISSN号 | 1466-8033 |
| DOI | 10.1039/c8ce00689j |
| 文献子类 | Article |
| 英文摘要 | Three isostructural cocrystals of apremilast, a novel anti-psoriasis oral agent, with nicotinamide, caffeine, and acetylsalicylic acid were successfully designed and synthesized. Both the apparent solubility and intrinsic dissolution rate of apremilast in a pH 2.0 buffer have been improved via the formation of cocrystals. |
| WOS关键词 | PHARMACEUTICAL COCRYSTALS ; CO-CRYSTALS |
| 资助项目 | Shanghai Natural Science Foundation[18ZR1447900] ; Youth Innovation Promotion Association CAS[2016257] ; CAS Key Technology Talent Program[00000000] ; SANOFI-SIBS Scholarship[00000000] |
| WOS研究方向 | Chemistry ; Crystallography |
| 语种 | 英语 |
| WOS记录号 | WOS:000448408200008 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279529]  |
| 专题 | 药物质量控制与固体化学研究中心 |
| 通讯作者 | Mei, Xuefeng |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Feng-Yuan,Zhang, Qi,Zhang, Zaiyong,et al. Solid-state characterization and solubility enhancement of apremilast drug-drug cocrystals[J]. CRYSTENGCOMM,2018,20(39):5945-5948. |
| APA | Wang, Feng-Yuan,Zhang, Qi,Zhang, Zaiyong,Gong, Xiaoyi,Wang, Jian-Rong,&Mei, Xuefeng.(2018).Solid-state characterization and solubility enhancement of apremilast drug-drug cocrystals.CRYSTENGCOMM,20(39),5945-5948. |
| MLA | Wang, Feng-Yuan,et al."Solid-state characterization and solubility enhancement of apremilast drug-drug cocrystals".CRYSTENGCOMM 20.39(2018):5945-5948. |
入库方式： OAI收割
来源：上海药物研究所
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