Fine-Tuning the Colors of Natural Pigment Emodin with Superior Stability through Cocrystal Engineering
文献类型：期刊论文
| 作者 | Li, Meiqi3,4; Zhang, Zhen1,3; Zhang, Qi3; Peng, Bo3; Zhu, Bin2; Wang, Jian-rong3 ; Liu, Liyu3,4; Mei, Xuefeng3
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| 刊名 | CRYSTAL GROWTH & DESIGN
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| 出版日期 | 2018-10 |
| 卷号 | 18期号:10页码:6123-6132 |
| ISSN号 | 1528-7483 |
| DOI | 10.1021/acs.cgd.8b01002 |
| 文献子类 | Article |
| 英文摘要 | Due to the increasing concern of toxicity when using synthetic pigments, naturally occurring materials have regained attention. However, the limited hues and instability restrict their applications. Emodin (EM) is considered as a naturally sourced pigment and has been added in chemic necessities for many years. In this work, continuous color changes can be achieved by careful selection of coformers via a cocrystal engineering approach. This fine color tuning could be attributed to the different pi-pi and charge-transfer interactions after cocrystal formation. Furthermore, EM cocrystals were found to have superior stability in formulations. Fine color modifications and better stability behaviors in cocrystals may provide a new pathway to develop naturally sourced pigments without chemical synthesis. |
| WOS关键词 | CO-CRYSTAL ; CANCER ; PATHWAY ; SUPPRESSION ; CHEMISTRY ; ANTITUMOR ; OXIDATION ; MICE |
| 资助项目 | Shanghai Natural Science Foundation[18ZR1447900] ; Youth Innovation Promotion Association CAS[2016257] ; CAS Key Technology Talent Program[00000000] ; SANOFI-SIBS Scholarship[00000000] |
| WOS研究方向 | Chemistry ; Crystallography ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000446923500048 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279558]  |
| 专题 | 药物质量控制与固体化学研究中心 |
| 通讯作者 | Mei, Xuefeng |
| 作者单位 | 1.Nanchang Univ, Coll Pharm, Nanchang 330006, Jiangxi, Peoples R China; 2.East China Univ Sci & Technol, Sch Pharm, Lab Pharmaceut Crystal Engn & Technol, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China; 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Meiqi,Zhang, Zhen,Zhang, Qi,et al. Fine-Tuning the Colors of Natural Pigment Emodin with Superior Stability through Cocrystal Engineering[J]. CRYSTAL GROWTH & DESIGN,2018,18(10):6123-6132. |
| APA | Li, Meiqi.,Zhang, Zhen.,Zhang, Qi.,Peng, Bo.,Zhu, Bin.,...&Mei, Xuefeng.(2018).Fine-Tuning the Colors of Natural Pigment Emodin with Superior Stability through Cocrystal Engineering.CRYSTAL GROWTH & DESIGN,18(10),6123-6132. |
| MLA | Li, Meiqi,et al."Fine-Tuning the Colors of Natural Pigment Emodin with Superior Stability through Cocrystal Engineering".CRYSTAL GROWTH & DESIGN 18.10(2018):6123-6132. |
入库方式： OAI收割
来源：上海药物研究所
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