Inhibition of dengue viral infection by diasarone-I is associated with 2'O methyltransferase of NS5
文献类型：期刊论文
| 作者 | Yao, Xingang4; Ling, Yun5; Guo, Songxin4; He, Shijun4 ; Wang, Jinan1; Zhang, Qing5; Wu, Wenyu2; Zou, Min4; Zhang, Tingting4; Nandakumar, Kutty Selva4
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| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
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| 出版日期 | 2018-02-15 |
| 卷号 | 821页码:11-20 |
| 关键词 | DENV2 Acorus tatarinowii Schott Diasarone-I 2'O methyltransferase |
| ISSN号 | 0014-2999 |
| DOI | 10.1016/j.ejphar.2017.12.029 |
| 文献子类 | Article |
| 英文摘要 | Dengue virus (DENV) is the most prevalent mosquito borne viral pathogen worldwide. However, antiviral drugs against this infection are not available. To identify novel anti-DENV compound from traditional Chinese medicine, we discovered the ethanol extract of Acorus tatarinowii Schott containing potent anti-DENV activity and diasarone-I was isolated from this extract. Diasarone-I has antiviral effect with half maximal effective concentration (EC50) of 4.5 mu M and half maximal cytotoxicity concentration (CC50) of > 80 mu M. Time of drug addition assay suggested that this compound inhibited at RNA replication step in the DENV life cycle. Further, in silico analysis indicated that diasarone-I might act as an inhibitor of 2'O Methyltransferase of NS5. Diasarone-I has also decreased the DENV2-induced STAT1 phosphorylation and ISGs. In summary, we suggest that diasarone-I may be a 2'O Methyltransferase inhibitor and might serve as a potential candidate for the treatment of DENV2 infections. |
| WOS关键词 | ACORUS-TATARINOWII SCHOTT ; BETA-ASARONE ; ANTIVIRAL ACTIVITY ; VIRUS-REPLICATION ; NS2B/NS3 PROTEASE ; INTERFERON ; VACCINE ; RIBAVIRIN ; DOMAIN |
| 资助项目 | Natural Science Foundation of China[81603118] ; Medical Scientific Research Foundation of Guangdong Province[A2016119] ; Southern Medical University[C1032242] ; Guangdong Provincial Key Laboratory of New Drug Screening, Educational Department of Jiangxi Province of China[GJJ151075] ; Natural Science Foundation of Jiangxi Province of China[20161BAB215194] ; Jiujiang University[2015LGYB35] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000425886200002 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279899]  |
| 专题 | 药物发现与设计中心 |
| 通讯作者 | Ling, Yun; Liu, Shuwen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 2.Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China; 3.Southern Med Univ, Sch Publ Hlth, Guangzhou 510515, Guangdong, Peoples R China 4.Southern Med Univ, Guangzhou Key Lab Drug Res Emerging Virus Prevent, Guangdong Prov Key Lab New Drug Screening, State Key Lab Organ Failure Res,Sch Pharmaceut Sc, Guangzhou 510515, Guangdong, Peoples R China; 5.Jiujiang Univ, Dept Pharmaceut & Life Sci, Jiujiang 332005, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yao, Xingang,Ling, Yun,Guo, Songxin,et al. Inhibition of dengue viral infection by diasarone-I is associated with 2'O methyltransferase of NS5[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2018,821:11-20. |
| APA | Yao, Xingang.,Ling, Yun.,Guo, Songxin.,He, Shijun.,Wang, Jinan.,...&Liu, Shuwen.(2018).Inhibition of dengue viral infection by diasarone-I is associated with 2'O methyltransferase of NS5.EUROPEAN JOURNAL OF PHARMACOLOGY,821,11-20. |
| MLA | Yao, Xingang,et al."Inhibition of dengue viral infection by diasarone-I is associated with 2'O methyltransferase of NS5".EUROPEAN JOURNAL OF PHARMACOLOGY 821(2018):11-20. |
入库方式： OAI收割
来源：上海药物研究所
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