Fluorescence Imaging of Alzheimer's Disease with a Flat Ensemble Formed between a Quinoline-Malononitrile AIEgen and Thin-Layer Molybdenum Disulfide
文献类型：期刊论文
| 作者 | Dou, Wei-Tao2; Zhang, Jing-Jing1; Li, Qiang2; Guo, Zhiqian2; Zhu, Weihong2; Chen, Guo-Rong2; Zhang, Hai-Yan1 ; He, Xiao-Peng2
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| 刊名 | Chembiochem : a European journal of chemical biology
 |
| 出版日期 | 2018-10-08 |
| ISSN号 | 1439-7633 |
| DOI | 10.1002/cbic.201800508 |
| 文献子类 | Article |
| 英文摘要 | The sensitive imaging of amyloid-β (Aβ) peptides is important for the timely detection of neurodegenerative diseases, such as Alzheimer's disease (AD). Although clinically the diagnosis of AD relies on the use of radiolabeled imaging reagents, herein we report the simple construction of a "flat ensemble" formed between a quinoline-malononitrile AIEgen (EDS) and thin-layer molybdenum disulfide (2D MoS ) for the sensitive detection of Aβ by means of fluorescence-based techniques. Self-assembly between EDS and 2D MoS in aqueous buffer solution produces the flat ensemble, and the subsequent interaction of the material ensemble with oligomeric and aggregated Aβ peptides leads to up to 19-fold enhanced fluorescence of EDS. The ensemble is also applicable for staining Aβ aggregates in vivo. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266547]  |
| 专题 | 新药研究国家重点实验室 药理学第二研究室 |
| 作者单位 | 1.CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, P.R. China 2.Key Laboratory for Advanced Materials and, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, P.R. China; |
| 推荐引用方式 GB/T 7714 | Dou, Wei-Tao,Zhang, Jing-Jing,Li, Qiang,et al. Fluorescence Imaging of Alzheimer's Disease with a Flat Ensemble Formed between a Quinoline-Malononitrile AIEgen and Thin-Layer Molybdenum Disulfide[J]. Chembiochem : a European journal of chemical biology,2018. |
| APA | Dou, Wei-Tao.,Zhang, Jing-Jing.,Li, Qiang.,Guo, Zhiqian.,Zhu, Weihong.,...&He, Xiao-Peng.(2018).Fluorescence Imaging of Alzheimer's Disease with a Flat Ensemble Formed between a Quinoline-Malononitrile AIEgen and Thin-Layer Molybdenum Disulfide.Chembiochem : a European journal of chemical biology. |
| MLA | Dou, Wei-Tao,et al."Fluorescence Imaging of Alzheimer's Disease with a Flat Ensemble Formed between a Quinoline-Malononitrile AIEgen and Thin-Layer Molybdenum Disulfide".Chembiochem : a European journal of chemical biology (2018). |
入库方式： OAI收割
来源：上海药物研究所
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