Bio-mimetic drug delivery systems designed to help the senior population reconstruct melatonin plasma profiles similar to those of the healthy younger population
文献类型：期刊论文
| 作者 | Li, Ying1,2; Wang, Liuyi3; Wu, Li4,5; Zhang, Xueju2; Li, Xue2; Guo, Zhen2; Li, Haiyan2 ; York, Peter2; Gui, Shuangying6; Zhang, Jiwen1,5,7
|
| 刊名 | Acta pharmaceutica Sinica. B
 |
| 出版日期 | 2014-02 |
| 卷号 | 4期号:1页码:60-6 |
| ISSN号 | 2211-3835 |
| DOI | 10.1016/j.apsb.2013.12.006 |
| 文献子类 | Article |
| 英文摘要 | The secretion of melatonin (MT) is obviously different in the younger and the senior sectors of the population, and the maximum plasma concentration of seniors is only half of that in the younger population group. If exogenous MT can be supplied to senior citizens based on the secretion rate and amount of endogenous MT in the younger population by a bio-mimetic drug delivery system (DDS), an improved therapeutic effect and reduced side effects can be expected. Based upon this hypothesis, the pharmacokinetic parameters of MT, namely, the absorption rate constant (k a), the elimination rate constant (k e), and the ratio of absorption rate (F) to the apparent volume of distribution (V) were obtained by a residual method depending on the plasma concentration curve of immediate release preparations in the healthy younger population. The dose-division method was applied to calculate the cumulative release profiles of MT achieved by oral administration of a controlled release drug delivery system (DDS) to generate plasma MT profiles similar to the physiological level-time profiles. The in vivo release of MT deduced from the healthy younger population physiological MT profiles as the pharmacokinetic output of the bio-mimetic DDS showed a two-phase profile with two different zero order release rates, namely, 4.919 μg/h during 0-4 h (r=0.9992), and 11.097 μg/h during 4-12 h (r=0.9886), respectively. Since the osmotic pump type of DDS generally exhibits a good correlation between in vivo and in vitro release behaviors, an osmotic pump controlled delivery system was designed in combination with dry coating technology targeting on the cumulative release characteristics to mimic the physiological MT profiles in the healthy younger population. The high similarity between the experimental drug release profiles and the theoretical profiles (similarity factor f 2>50) and the high correlation between the predicted plasma concentration profiles and the theoretical plasma concentration profiles (r=0.9366, 0.9163, 0.9264) indicated that a prototype bio-mimetic drug delivery system of MT was established. The similarity factors between the experimental drug release profiles and the theoretical release profile were all larger than 50 both in periods of 0-4 h and 4-12 h, namely, 68.8 and 57.3 for the first batch (Batch No. 20131031), 76.7 and 50.2 for the second batch (Batch No. 20131101), and 73.7 and 51.1 for the third batch (Batch No. 20131126), respectively. The correlation coefficients between the predicted plasma concentration profiles based on the release profiles of the bio-mimetic DDS and physiological profiles were 0.9366 (Batch No. 20131031), 0.9163 (Batch No. 20131101), 0.9264 (Batch No. 20131126), respectively. Since the pharmacokinetic profile of MT in any kind of animal differs markedly from that of human beings, it is impossible to test the bio-mimetic DDS in animals directly. Therefore, the predicted pharmacokinetic profile based upon the in vitro release kinetics is an acceptable surrogate for the conventional animal test. In this research, a bio-mimetic DDS for replacement of MT was designed with in silico evaluation. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266828]  |
| 专题 | 药物化学研究室 药物制剂研究中心 |
| 作者单位 | 1.Anhui University of Chinese Medicine, Hefei 230038, China ; 2.Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; 3.Hainan Weikang Pharmaceutical (Qianshan) Co., Ltd, Anqing 246000, China; 4.Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China ; 5.College of Life Sciences, Jilin University, Changchun 130012, China; 6.Anhui University of Chinese Medicine, Hefei 230038, China; 7.Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China |
| 推荐引用方式 GB/T 7714 | Li, Ying,Wang, Liuyi,Wu, Li,et al. Bio-mimetic drug delivery systems designed to help the senior population reconstruct melatonin plasma profiles similar to those of the healthy younger population[J]. Acta pharmaceutica Sinica. B,2014,4(1):60-6. |
| APA | Li, Ying.,Wang, Liuyi.,Wu, Li.,Zhang, Xueju.,Li, Xue.,...&Zhang, Jiwen.(2014).Bio-mimetic drug delivery systems designed to help the senior population reconstruct melatonin plasma profiles similar to those of the healthy younger population.Acta pharmaceutica Sinica. B,4(1),60-6. |
| MLA | Li, Ying,et al."Bio-mimetic drug delivery systems designed to help the senior population reconstruct melatonin plasma profiles similar to those of the healthy younger population".Acta pharmaceutica Sinica. B 4.1(2014):60-6. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。