Paeoniflorin attenuates the impairment of learning behavior and hippocampal neuron apoptosis caused by chronic cerebral hypoperfusion in rats
文献类型：会议论文
| 作者 | Liu J(刘静); Ji XQ(季新泉); Zhu XZ(朱兴族) |
| 出版日期 | 2005-10-01 |
| 关键词 | paeoniflorin dementia chronic cerebral hypoperfu |
| 卷号 | 21 |
| 页码 | 1 |
| 英文摘要 | Paeoniflorin (PF), a major constituent of peony root (Paeonia lactiflora PALLAS), was proved to be neuroprotective in middle cerebral artery occlusion model. Because peony root has long been used as a component of traditional Chinese prescriptions to treat certain types of dementia, we investigated whether PF attenuates cognitive damage in rats with chronic cerebral hypoperfusion. PF (1.25 and 2.5 mg/kg) were administered s.c. after surgery. Sham-operated animals served as control for the surgery. Eight weeks after the onset of cerebral hypoperfusion, the rats were tested in a hippocampus-related learning paradigm, the Morris water maze. PF (2.5 mg/kg) restored cerebral hypoperfusion-related learning dysfunction and prevented CA1 neuron loss. Cerebral hypoperfusion led to activate glia cell and promote the expressions of nucler factor-kappa B (NF-κB), and PF could modify these changes. We conclude that PF attenuates cognitive deficit and neuron damage by suppressing glia cell activation and the expression of NF-kB in glia cells. |
| 会议录 | 中国神经科学学会第六届学术会议暨学会成立十周年庆祝大会论文摘要汇编
 |
| 文献子类 | Article |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267569]  |
| 专题 | 药理学第二研究室 |
| 推荐引用方式 GB/T 7714 | Liu J,Ji XQ,Zhu XZ. Paeoniflorin attenuates the impairment of learning behavior and hippocampal neuron apoptosis caused by chronic cerebral hypoperfusion in rats[C]. 见:. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。