Application of methyl in drug design
文献类型：期刊论文
| 作者 | Lian Jie2; Wang Jiang1 ; Sun Haifeng1; Lin Daizong1; Liu Hong2
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2013 |
| 卷号 | 48期号:8页码:1195-1208 |
| 关键词 | methyl drug design lead optimization stereoelectronic effect liposolubility |
| ISSN号 | 0513-4870 |
| 其他题名 | 甲基在药物分子设计中的应用 |
| 文献子类 | Review |
| 英文摘要 | The methyl group plays an important role in the rational drug design. Introducing methyl into small molecules has become an important strategy of lead compound optimization. The application of methyl in drug design is reviewed in this paper. Methyl can modulate the physicochemical, pharmacodynamic, and pharmacokinetic properties by ortho effect, inductive effect, and conformational effect. It also improves the metabolic stability as a soft metabolic point. In addition, introducing methyl into drug molecules can also be applied as a strategy in new uses of old drugs and generate me-too drugs. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4908839 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267763]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Liu Hong |
| 作者单位 | 1.State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. 2.School of Pharmacy,China Pharmaceutical University, State Key Laboratory of Drug Research, Nanjing, Jiangsu 210009, China.; |
| 推荐引用方式 GB/T 7714 | Lian Jie,Wang Jiang,Sun Haifeng,et al. Application of methyl in drug design[J]. Acta Pharmaceutica Sinica,2013,48(8):1195-1208. |
| APA | Lian Jie,Wang Jiang,Sun Haifeng,Lin Daizong,&Liu Hong.(2013).Application of methyl in drug design.Acta Pharmaceutica Sinica,48(8),1195-1208. |
| MLA | Lian Jie,et al."Application of methyl in drug design".Acta Pharmaceutica Sinica 48.8(2013):1195-1208. |
入库方式： OAI收割
来源：上海药物研究所
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