Progress in folate receptor-mediated anticancer agent delivery
文献类型：期刊论文
| 作者 | Fu Liqiang; Ding Shi; Yang Yushe
|
| 刊名 | Chinese Journal of Medicinal Chemistry
 |
| 出版日期 | 2013 |
| 卷号 | 23期号:3页码:226-234 |
| 关键词 | folate receptor endocytosis folate conjugate anticancer drug |
| ISSN号 | 1005-0108 |
| 其他题名 | 叶酸受体介导的小分子抗肿瘤药物研究进展 |
| 文献子类 | Review |
| 英文摘要 | Cancer therapies that exploit targeting ligands to deliver attached cytotoxic drugs selectively to malignant cells are currently receiving significant attention.The folate receptor(FR) is a confirmed tumor-associated antigen that binds folate and folate-drug conjugates with very high affinity and shuttles these bound molecules inside cells via an endocytic mechanism.With the use of proper linkers and cleavable bond,small molecular weight,highly potent anticancer drugs can be released inside the cancer cells where they can perform their desired cytotoxic functions.This review summarizes published activity data of various conjugates and highlights some newly emerging data from novel compounds which are currently under clinical investigation. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4852862 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267777]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Yang Yushe |
| 作者单位 | State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Fu Liqiang,Ding Shi,Yang Yushe. Progress in folate receptor-mediated anticancer agent delivery[J]. Chinese Journal of Medicinal Chemistry,2013,23(3):226-234. |
| APA | Fu Liqiang,Ding Shi,&Yang Yushe.(2013).Progress in folate receptor-mediated anticancer agent delivery.Chinese Journal of Medicinal Chemistry,23(3),226-234. |
| MLA | Fu Liqiang,et al."Progress in folate receptor-mediated anticancer agent delivery".Chinese Journal of Medicinal Chemistry 23.3(2013):226-234. |
入库方式： OAI收割
来源：上海药物研究所
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