中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 药理学第二研究室
Molecular mechanisms and function of intracellular GABA_A receptor transportation

文献类型：期刊论文

作者Tang Jianxing1; Wang Weisheng2; Ji Hui1; Liu Jinggen2
刊名Journal of China Pharmaceutical University
出版日期2013
卷号44期号:2页码:182-187
关键词GABA_A receptors receptor trafficking somnipathy epilepsy drug abuse
ISSN号1000-5048
其他题名gamma-氨基丁酸A型受体转运的胞内调节机制及其功能研究进展
文献子类Review
英文摘要Inhibition of the central nervous system (CNS) is mainly mediated by GABAergic neurons, its nervous transmission is important for all aspects of CNS function. The effects of central GABAergic system are mainly mediated by both GABA_A receptors, which belong to the superfamily of heteropentameric ligand-gated ion channels, and GABA_B receptors, which belong to superfamily of G-protein coupled heptahelical transmembrane receptors. Fast synaptic inhibition in the mammalian brain is mainly mediated by GABA_A receptors. In this chapter, we summarized recent findings on the molecular mechanisms of intracellular transportation and functions of GABA_A receptors, and discussed the regulating roles of post-translational modifications, GABA_A receptors associated proteins, scaffold proteins, enzymes etc in this process. Finally, we highlighted a number of neuropsychical diseases, in which confusion of GABA_A receptors trafficking occured.
资助项目国家重点基础研究发展计划("九七三计划)资助项目[00000000] ; "十二五国家科技支撑计划重大专项资助项目[00000000]
WOS研究方向Pharmacology & Pharmacy ; General & Internal Medicine (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:4816352
源URL[http://119.78.100.183/handle/2S10ELR8/267782]  
专题药理学第二研究室
作者单位1.Department of Pharmacology,China Pharmaceutical University, Nanjing, Jiangsu 210009, China.;
2.State Key Laboratory of New Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式
GB/T 7714		 Tang Jianxing,Wang Weisheng,Ji Hui,et al. Molecular mechanisms and function of intracellular GABA_A receptor transportation[J]. Journal of China Pharmaceutical University,2013,44(2):182-187.
APA Tang Jianxing,Wang Weisheng,Ji Hui,&Liu Jinggen.(2013).Molecular mechanisms and function of intracellular GABA_A receptor transportation.Journal of China Pharmaceutical University,44(2),182-187.
MLA Tang Jianxing,et al."Molecular mechanisms and function of intracellular GABA_A receptor transportation".Journal of China Pharmaceutical University 44.2(2013):182-187.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。