Application of phosphates and phosphonates prodrugs in drug research and development
文献类型：期刊论文
| 作者 | Ji Xun1; Wang Jiang1 ; Zhang Lei1; Zhao Linxiang2; Jiang Hualiang1; Liu Hong1
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2013 |
| 卷号 | 48期号:5页码:621-634 |
| 关键词 | prodrugs of phosphates and phosphonates bioavailability lipophilicity solubility stability HepDirect prodrug |
| ISSN号 | 0513-4870 |
| 其他题名 | 磷酸酯前药在药物研究中的应用 |
| 文献子类 | Review |
| 英文摘要 | Based on the character of the molecular structure, the prodrugs of phosphates and phosphonates were divided into two categories. The first is the drug which contained the phosphate group, introducing protected groups to increase lipophilicity and improve bioavailability. The other one is the drug which had no phosphate group, introducing the phosphate group into molecules to enhance the solubility, regulate the distribution coefficient and enhance the drug-like property. This review focuses on the application of phosphates and phosphonates in drug research and development based on improvement of physico-chemical property, drug safety and the pharmacokinetics. |
| 资助项目 | 国家杰出青年科学基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4819459 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267783]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Liu Hong |
| 作者单位 | 1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; 2.School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China. |
| 推荐引用方式 GB/T 7714 | Ji Xun,Wang Jiang,Zhang Lei,et al. Application of phosphates and phosphonates prodrugs in drug research and development[J]. Acta Pharmaceutica Sinica,2013,48(5):621-634. |
| APA | Ji Xun,Wang Jiang,Zhang Lei,Zhao Linxiang,Jiang Hualiang,&Liu Hong.(2013).Application of phosphates and phosphonates prodrugs in drug research and development.Acta Pharmaceutica Sinica,48(5),621-634. |
| MLA | Ji Xun,et al."Application of phosphates and phosphonates prodrugs in drug research and development".Acta Pharmaceutica Sinica 48.5(2013):621-634. |
入库方式： OAI收割
来源：上海药物研究所
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