A Progress in pharmaceutical studies of huperzine A
文献类型：期刊论文
| 作者 | Lei Yun; Gan Yong ; Zhang Haiyan
|
| 刊名 | Chinese Journal of New Drugs and Clinical Remedies
 |
| 出版日期 | 2012 |
| 卷号 | 31期号:12页码:713-718 |
| 关键词 | huperzine A Alzheimer disease pharmaceutics |
| ISSN号 | 1007-7669 |
| 其他题名 | 石杉碱甲新剂型研究进展 |
| 文献子类 | Review |
| 英文摘要 | Huperzine A is a potent, highly specific inhibitor of acetylcholinesterase in central nervous system, which has been widely used in the treatment for Alzheimer's disease (AD). Huperzine A is commonly available in the market as oral or injectable formulation, which has to be given several times per day. This multi - time administration is not convenient enough for the old patients with memory deficiency. It could also cause a large fluctuation of drug concentration, and may in turn induce peripheral cholinergic side effects. Therefore, it is necessary to develop novel drug formulation with optimized delivery system. In the present review, an attempt is made to discuss the current progress of huperzine A in pharmaceutics, including sustained - release tablet, injectable microsphere, transdermal patch and intranasal brain targeting gel. Meanwhile, novel drug administration strategy is proposed with the evidence about close association between central acetylcholine level and memory ability, aiming at offering useful information for developing more efficient and convenient huperzine A products. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4751099 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267804]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Zhang Haiyan |
| 作者单位 | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica,Chinese Academy of Sciences, SHANGHAI 201203, China. |
| 推荐引用方式 GB/T 7714 | Lei Yun,Gan Yong,Zhang Haiyan. A Progress in pharmaceutical studies of huperzine A[J]. Chinese Journal of New Drugs and Clinical Remedies,2012,31(12):713-718. |
| APA | Lei Yun,Gan Yong,&Zhang Haiyan.(2012).A Progress in pharmaceutical studies of huperzine A.Chinese Journal of New Drugs and Clinical Remedies,31(12),713-718. |
| MLA | Lei Yun,et al."A Progress in pharmaceutical studies of huperzine A".Chinese Journal of New Drugs and Clinical Remedies 31.12(2012):713-718. |
入库方式： OAI收割
来源：上海药物研究所
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