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THE EFFECTS OF JITAI TABLET ON THE PAIN AND WITHDRAWAL SYMPTOMSPRECIPITATED BY NALOXONE IN MORPHINE DEPENDENT MICE

文献类型：期刊论文

作者Wang Jun2; Jiang Lihe4; Wang Yuhua3; Tao Yimin4; Chen Jie4; Xu Xuejun4; Xi Tao3; Liu Jinggen4
刊名Chinese Journal of Drug Dependence
出版日期2012
卷号21期号:3页码:170
关键词JITAI Tablet analgesia writhing test hot-plate test dose increasing method withdrawal syndromes
ISSN号1007-9718
其他题名济泰片对小鼠诱发性疼痛及对吗啡躯体依赖小鼠戒断症状的影响
文献子类Article
英文摘要Objective:To observe the analgesic effect of JITAI Tablet on induced pain in mice and the withdrawal symptoms of morphine-induced physical dependence.Methods:The analgesic effects of JITAI Tablet at different concentrations were measured by writhing induced by acetic acid(2.4 g·kg~(-1),3.6 g·kg~(-1),4.8 g·kg~(-1)) and hot-plate tests(6.0 g·kg~(-1),9.0 g·kg~(-1),12.0 g·kg~(-1)).Withdrawal syndromes precipitated by naloxone after given increasing doses of morphine and the effect of JITAI Tablet at differential concentrations(1.2 g·kg~(-1),2.4 g·kg~(-1),3.6 g·kg~(-1)) on naloxone-precipitated jumping was examined.Results:JITAI Tablet significantly reduced the writhing frequency induced by acetic acid and the maximal inhibition value is 71.7%.It was found that JITAI Tablet also obviously enhanced the pain threshold in hot-plate test with the ED50 value of 8.34 g·kg~(-1).Importantly,JITAI Tablet obviously decreased the number of jumping caused by injection of naloxone(P<0.01).Conclusion:JITAI Tablet had obvious analgesia effects and could inhibit withdrawal symptoms precipitated by naloxone.
资助项目国家科技支撑计划[00000000]
WOS研究方向Neurosciences & Neurology (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:4570833
源URL[http://119.78.100.183/handle/2S10ELR8/267832]  
专题药理学第二研究室
通讯作者Liu Jinggen
作者单位1.Nanjing, Jiangsu 210009, China.;
2.School of Life Science and Technology,China Pharmaceutical University;
3.School of Life Science and Technology,China Pharmaceutical University, Nanjing, Jiangsu 210009, China.
4.State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.;
推荐引用方式
GB/T 7714		 Wang Jun,Jiang Lihe,Wang Yuhua,et al. THE EFFECTS OF JITAI TABLET ON THE PAIN AND WITHDRAWAL SYMPTOMSPRECIPITATED BY NALOXONE IN MORPHINE DEPENDENT MICE[J]. Chinese Journal of Drug Dependence,2012,21(3):170.
APA Wang Jun.,Jiang Lihe.,Wang Yuhua.,Tao Yimin.,Chen Jie.,...&Liu Jinggen.(2012).THE EFFECTS OF JITAI TABLET ON THE PAIN AND WITHDRAWAL SYMPTOMSPRECIPITATED BY NALOXONE IN MORPHINE DEPENDENT MICE.Chinese Journal of Drug Dependence,21(3),170.
MLA Wang Jun,et al."THE EFFECTS OF JITAI TABLET ON THE PAIN AND WITHDRAWAL SYMPTOMSPRECIPITATED BY NALOXONE IN MORPHINE DEPENDENT MICE".Chinese Journal of Drug Dependence 21.3(2012):170.

入库方式： OAI收割

来源：上海药物研究所

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