Protein-Protein Interactions Studied by NMRA Review Using the Ubiquitin-Proteasome Pathway as An Example
文献类型：期刊论文
| 作者 | Zhang Naixia ; Wu Juan; Zhang Huaqun; Liu Xia
|
| 刊名 | Chinese Journal of Magnetic Resonance
 |
| 出版日期 | 2012 |
| 卷号 | 29期号:2页码:182-189 |
| 关键词 | NMR chemical shift perturbation nuclear Overhauser effect paramagnetic relaxation enhancement residual dipolar coupling ubiquitin-proteasome pathway |
| ISSN号 | 1000-4556 |
| 其他题名 | NMR技术在蛋白质-蛋白质相互作用研究中的应用泛素-蛋白水解酶体通路研究实例介绍 |
| 文献子类 | Review |
| 英文摘要 | Protein-protein interactions(PPIs) play key roles in multiple cellular processes.Both X-ray crystallography and NMR techniques are commonly used to illustrate the structural basis of PPIs.Although most of the available structures of protein complexes are determined by X-ray crystallography,NMR proves to be the technique of choice under special circumstances such as crystallization-resistance,weak binding,and complicated dynamic behavior presented by protein complexes.Chemical shift perturbation analysis,inter-molecular NOE detection,paramagnetic relaxation enhancement and residual dipolar coupling detection are the four major NMR techniques used for studing PPI.The principles and strengths of these NMR techniques and their applications in studying the ubiquitin-proteasome pathway are reviewed in this article. |
| 资助项目 | 中国科学院百人计划资助项目[00000000] |
| WOS研究方向 | Gastroenterology & Hepatology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4555791 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267834]  |
| 专题 | 分析化学研究室 |
| 通讯作者 | Zhang Naixia |
| 作者单位 | Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Zhang Naixia,Wu Juan,Zhang Huaqun,et al. Protein-Protein Interactions Studied by NMRA Review Using the Ubiquitin-Proteasome Pathway as An Example[J]. Chinese Journal of Magnetic Resonance,2012,29(2):182-189. |
| APA | Zhang Naixia,Wu Juan,Zhang Huaqun,&Liu Xia.(2012).Protein-Protein Interactions Studied by NMRA Review Using the Ubiquitin-Proteasome Pathway as An Example.Chinese Journal of Magnetic Resonance,29(2),182-189. |
| MLA | Zhang Naixia,et al."Protein-Protein Interactions Studied by NMRA Review Using the Ubiquitin-Proteasome Pathway as An Example".Chinese Journal of Magnetic Resonance 29.2(2012):182-189. |
入库方式： OAI收割
来源：上海药物研究所
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