Structure modification strategies to improve drug permeability of the blood-brain barrier
文献类型：期刊论文
| 作者 | Chen Hongli1; Jiang Biao1; Li Yuanchao2 |
| 刊名 | Chinese Journal of Medicinal Chemistry
 |
| 出版日期 | 2011 |
| 卷号 | 21期号:6页码:489 |
| 关键词 | blood-brain barrier structure modification passive diffusion carrier-mediated transport |
| ISSN号 | 1005-0108 |
| 其他题名 | 结构修饰策略改善药物血脑屏障通透性 |
| 文献子类 | Review |
| 英文摘要 | How to make drugs cross the blood-brain barrier and show therapeutic effects is the major challenge for the treatment of central nervous system diseases.The physicochemical properties of small molecular drugs can be improved through structure modification and the drugs can get to brain by means of passive diffusion.Drugs can also be modified to the structure which can be transported by carrier-mediated transport system or receptor-mediated transport system,reaching brain.These two chemical methods are common strategies currently to improve drug permeability of the blood-brain barrier.In this paper,the main ways of delivering drugs to brain will be briefly introduced and improving the permeability of small molecular drugs through structure modification will be reviewed. |
| 资助项目 | 国家自然科学基金项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4410726 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267863]  |
| 专题 | 药物化学研究室 |
| 作者单位 | 1.Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Chen Hongli,Jiang Biao,Li Yuanchao. Structure modification strategies to improve drug permeability of the blood-brain barrier[J]. Chinese Journal of Medicinal Chemistry,2011,21(6):489. |
| APA | Chen Hongli,Jiang Biao,&Li Yuanchao.(2011).Structure modification strategies to improve drug permeability of the blood-brain barrier.Chinese Journal of Medicinal Chemistry,21(6),489. |
| MLA | Chen Hongli,et al."Structure modification strategies to improve drug permeability of the blood-brain barrier".Chinese Journal of Medicinal Chemistry 21.6(2011):489. |
入库方式： OAI收割
来源：上海药物研究所
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