Interaction of Proteins with Metal Ions Studied by NMR Techniques: A Review
文献类型：期刊论文
| 作者 | ZHANG Fang; LIN Dong-hai |
| 刊名 | Chinese Journal of Magnetic Resonance
 |
| 出版日期 | 2009 |
| 卷号 | 26期号:1页码:136-149 |
| 关键词 | NMR protein-metal ion interaction chemical shift mapping backbone dynamics paramagnetic effect 3D structure. |
| ISSN号 | 1000-4556 |
| 其他题名 | 用核磁共振方法研究金属离子与蛋白质的相互作用 |
| 文献子类 | Article |
| 英文摘要 | Metal ions interact with protein using a great variety of mechanisms to regulate protein functions. Some metal ions bind tightly and specifically to proteins and markedly regulate protein function, while others interact loosely and nonspecifically with proteins and only act as cofactors for protein functioning. In this review, we describe nuclear magnetic resonance (NMR) techniques which are widely used to investigate inter-molecular interactions between proteins and diamagnetic/paramagnetic metal ions. Special emphasis is put on the NMR techniques the can be used to elucidate the structure and function of metalloproteins, including chemical shift mapping, paramagnetic NMR and backbone dynamics detection. Examples are given to illustrate how the NMR techniques can be used to map inter-molecular interaction between proteins (calmodulin, zinc fingers and prion proteins) and metal ions. |
| 资助项目 | 国家自然科学基金[00000000] |
| WOS研究方向 | Physics ; Biochemistry & Molecular Biology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3552302 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268014]  |
| 专题 | 分析化学研究室 |
| 作者单位 | Shanghai Institute of Marteria Medica, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | ZHANG Fang,LIN Dong-hai. Interaction of Proteins with Metal Ions Studied by NMR Techniques: A Review[J]. Chinese Journal of Magnetic Resonance,2009,26(1):136-149. |
| APA | ZHANG Fang,&LIN Dong-hai.(2009).Interaction of Proteins with Metal Ions Studied by NMR Techniques: A Review.Chinese Journal of Magnetic Resonance,26(1),136-149. |
| MLA | ZHANG Fang,et al."Interaction of Proteins with Metal Ions Studied by NMR Techniques: A Review".Chinese Journal of Magnetic Resonance 26.1(2009):136-149. |
入库方式： OAI收割
来源：上海药物研究所
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