Advances in the inhibitors of vascular endothelial growth factor receptor tyrosine kinase
文献类型：期刊论文
| 作者 | MAO Yongjun4; ZHANG Peixuan4; TIAN Guanghui3; WANG Zhen4 ; SHEN Jingshan4
|
| 刊名 | Chinese Journal New Drugs
 |
| 出版日期 | 2008 |
| 卷号 | 17期号:7页码:544-550 |
| 关键词 | signal transduction tumor angiogenesis vascular endothelial growth factor receptor(VEGFR) tyrosine kinase inhibitors(TKIs) antitumor agents |
| ISSN号 | 1003-3734 |
| 其他题名 | 血管内皮生长因子受体酪氨酸激酶抑制剂的研究进展 |
| 文献子类 | Review |
| 英文摘要 | Angiogenesis is critical to the growth,metastasis and progression of solid tumors.In this review,the RAS/Raf/MAPK,PI3K/AKT,PLC-gamma and Src signal pathways operated by vascular endothelial growth factor receptor(VEGFR) tyrosine kinases was briefly illuminated,and several small-molecular VEGFR tyrosine kinase inhibitors(TKIs,some of which are approved) were summarized.According to different structures,TKIs include indolinones,quinazolines,phthalazines,indazoles,nicotinamides,pyrrolopyrimidines and so on.The pre-clinical and clinical research data of some representative compounds are depicted in this review. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3305314 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268048]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | SHEN Jingshan |
| 作者单位 | 1.Shanghai 201209, China. 2.Shanghai 201203, China.; 3.Topharman Shanghai Co.; 4.Shanghai Institute of Materia Medica; |
| 推荐引用方式 GB/T 7714 | MAO Yongjun,ZHANG Peixuan,TIAN Guanghui,et al. Advances in the inhibitors of vascular endothelial growth factor receptor tyrosine kinase[J]. Chinese Journal New Drugs,2008,17(7):544-550. |
| APA | MAO Yongjun,ZHANG Peixuan,TIAN Guanghui,WANG Zhen,&SHEN Jingshan.(2008).Advances in the inhibitors of vascular endothelial growth factor receptor tyrosine kinase.Chinese Journal New Drugs,17(7),544-550. |
| MLA | MAO Yongjun,et al."Advances in the inhibitors of vascular endothelial growth factor receptor tyrosine kinase".Chinese Journal New Drugs 17.7(2008):544-550. |
入库方式： OAI收割
来源：上海药物研究所
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