Synthesis of an antitumor agent neratinib
文献类型：期刊论文
| 作者 | ZHANG Peixuan2; MAO Yongjun1; SHEN Jingshan1 ; WEI Yabing2
|
| 刊名 | Chinese Journal of Medicinal Chemistry
 |
| 出版日期 | 2008 |
| 卷号 | 18期号:5页码:355-357 |
| 关键词 | neratinib（HKI-272） chemical synthesis tyrosine kinases inhibitors antitumor agent neratinib（HKI-272） |
| ISSN号 | 1005-0108 |
| 其他题名 | 抗肿瘤药物neratinib的合成 |
| 文献子类 | Article |
| 英文摘要 | Aim To synthesize neratinib.Methods Starting from 2-chloro-4-nitrophenol and 2-(chloromethyl)pyridine hydrochlorid,3-chloro-4-(pyridin-2-ylmethoxy)aniline was obtained via etherization and reduction.The obtained aniline coupled with N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl) acetamide to give 4-[3-chloro-4-(2-pyridylmethoxy)phenylamino]-3-cyano-7-ethoxy-6-N-acetylaminoquinoline.And then it was deacetylated,followed by reacting with(E)4-(dimethylamino)but-2-enoyl chloride to yield the target compound neratinib.Results and conclusion The overall yield of this method is 56.0%.The structure of neratinib was confirmed by 1H-NMR,and MS. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3445423 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268062]  |
| 专题 | 药物化学研究室 |
| 作者单位 | 1.Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, China. 2.College of Materials Science and Engineering Nanjing University of Technology, Nanjing, Jiangsu 210009, China.; |
| 推荐引用方式 GB/T 7714 | ZHANG Peixuan,MAO Yongjun,SHEN Jingshan,et al. Synthesis of an antitumor agent neratinib[J]. Chinese Journal of Medicinal Chemistry,2008,18(5):355-357. |
| APA | ZHANG Peixuan,MAO Yongjun,SHEN Jingshan,&WEI Yabing.(2008).Synthesis of an antitumor agent neratinib.Chinese Journal of Medicinal Chemistry,18(5),355-357. |
| MLA | ZHANG Peixuan,et al."Synthesis of an antitumor agent neratinib".Chinese Journal of Medicinal Chemistry 18.5(2008):355-357. |
入库方式： OAI收割
来源：上海药物研究所
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