Study on Design, Synthesis and Insuli N-Sensitizing Activity of Malonic Acid Derivatives
文献类型：期刊论文
| 作者 | TANG Lei2; YANG Yushe1 ; JI Ruyun1
|
| 刊名 | Chinese Pharmaceutical Journal
 |
| 出版日期 | 2007 |
| 卷号 | 42期号:11页码:866-872 |
| 关键词 | insulin-sensitizing activity 3T3-L1 cells type 2 diabetes |
| ISSN号 | 1001-2494 |
| 其他题名 | 一类丙二酸衍生物的设计、合成及胰岛素增敏活性研究 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVE To design and synthesize compounds with insulin-sensitizing activity.METHODS Using isosterisms and analogues generation principle of drug design,19 title compounds were designed and synthesized on the basis of known compounds with insulin-sensitizing activity,and their insulin-sensitizing activity was evaluated in 3T3-L1 pre-adipocyte cells.RESULTS Three of the synthesized compounds showed strong insulin-sensitizing activity in vitro. CONCLUSION These compounds might possess good sugar-lowering activity,and are selected for further hypoglycemic evaluation in vivo. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2823136 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268124]  |
| 专题 | 药物化学研究室 |
| 作者单位 | 1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. 2.School of Pharmacy, Guiyang Medical College, Guiyang, Guizhou 550004, China.; |
| 推荐引用方式 GB/T 7714 | TANG Lei,YANG Yushe,JI Ruyun. Study on Design, Synthesis and Insuli N-Sensitizing Activity of Malonic Acid Derivatives[J]. Chinese Pharmaceutical Journal,2007,42(11):866-872. |
| APA | TANG Lei,YANG Yushe,&JI Ruyun.(2007).Study on Design, Synthesis and Insuli N-Sensitizing Activity of Malonic Acid Derivatives.Chinese Pharmaceutical Journal,42(11),866-872. |
| MLA | TANG Lei,et al."Study on Design, Synthesis and Insuli N-Sensitizing Activity of Malonic Acid Derivatives".Chinese Pharmaceutical Journal 42.11(2007):866-872. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。