Inhibitation of Coumarins in Cnidium monnieri Cusson and Angelian dahuricn on PDE5
文献类型：期刊论文
| 作者 | WEI Xiaohui2; ZHANG Shujun2; XIA Guangxin2; FU Shou1; WANG Wei1; SHEN Jingshan2 ; JI Ruyun2
|
| 刊名 | Chinese Pharmaceutical Journal
 |
| 出版日期 | 2006 |
| 卷号 | 41期号:2页码:100-102 |
| 关键词 | Cnidium monnieri （L.） Cusson Angelica dahurica benth.et Hook. coumarins PDE5 inhibitor |
| ISSN号 | 1001-2494 |
| 其他题名 | 蛇床子和白芷中香豆素类化合物抑制磷酸二酯酶5活性的研究 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVE To study the activity of coumarins as PDF25 inhibitor.METHODS The coumarins were extracted with 95% alcohol from Cnidium monnieri （L.） Cusson and with CHCl3 from Angelica dahurica Benth. et Hook., and then isolated via column chromatography and HPLC. After structure identification, the inhibition of compotmds on PDE5 was investigated according to the existing methods. RESULTS 8 compotmds were isolated and identified, and 4 compounds were obtained by structure, modification. The activities data as PDE5 inhibitors were tested. CONCLUSION Osthol showes the potent inhibitation on PDE5. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2337114 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268196]  |
| 专题 | 药物化学研究室 |
| 作者单位 | 1.Topfond Pharmaceutical Inc, Zhumodian, 463000. 2.Shanghai Institute of Materia Medica , Shanghai Institutes for Biological Sciences , Chinese Academy of Sciences, Shanghai 201203, China.; |
| 推荐引用方式 GB/T 7714 | WEI Xiaohui,ZHANG Shujun,XIA Guangxin,et al. Inhibitation of Coumarins in Cnidium monnieri Cusson and Angelian dahuricn on PDE5[J]. Chinese Pharmaceutical Journal,2006,41(2):100-102. |
| APA | WEI Xiaohui.,ZHANG Shujun.,XIA Guangxin.,FU Shou.,WANG Wei.,...&JI Ruyun.(2006).Inhibitation of Coumarins in Cnidium monnieri Cusson and Angelian dahuricn on PDE5.Chinese Pharmaceutical Journal,41(2),100-102. |
| MLA | WEI Xiaohui,et al."Inhibitation of Coumarins in Cnidium monnieri Cusson and Angelian dahuricn on PDE5".Chinese Pharmaceutical Journal 41.2(2006):100-102. |
入库方式： OAI收割
来源：上海药物研究所
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