Studies on Treatment of Menopausal Syndrome with Angeng Capsules
文献类型：期刊论文
| 作者 | FANG Liang1; WEI Xiaohui2; HE Qiaojun1; LUO Peihua1; FAN Lingling1; YANG Bo1; SHEN Jingshan2
|
| 刊名 | Chinese Pharmaceutical Journal
 |
| 出版日期 | 2006 |
| 卷号 | 41期号:22页码:1741-1744 |
| 关键词 | angeng capsules menopausal syndrome phaimacodynamics |
| ISSN号 | 1001-2494 |
| 其他题名 | 安更胶囊治疗女性更年期综合征的药效学研究 |
| 文献子类 | Article |
| 英文摘要 | To evaluate the pre-clinical effect of Angeng capsules on treatment of menopausal syndrome in mice and rat models. METHODS The sleep enhancement action with pentobarbital sodium (PS) was observed in pre-treated mice model.Trie analgesic effect was observed with writhing test.Antidiaphoresis action was observed with pilocarpine in pre-LreaLed mice model.The antidepressant action was evaluated with forced swimming test and tail suspension test.The effect on the serum level of estradiol, androgen, LH and FSH was determined in castrated female rat. RESULTS Angeng capsules (> 0.41 g·kg~(-1)) significantly enhanced the sleeping time in mice pre-treated with PS. When the close was above 1.65 g·kg~(-1), Angeng capsules significantly reduced the frequency of writhing and diaphoresis; Angeng capsules (>3.3 g·kg~(-1)) significantly increased swimming time in forced swimming test and moving time in tail suspension test. Angeng capsules showed no significant effect on the E2, T and FSH level in rat serum, but made a significant decline of LH level in the serum. CONCLUSION Angeng capsules can promote sleep, exert antidepressant, antifatigue and analgesic effect, and inhibit the secretion of sweat glands without decreasing serum estrodial level. It's a promising anti-menopausal syndrome Chinese herbal medicine. |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2657542 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268203]  |
| 专题 | 药物化学研究室 |
| 作者单位 | 1.Department of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310031, China.; 2.Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | FANG Liang,WEI Xiaohui,HE Qiaojun,et al. Studies on Treatment of Menopausal Syndrome with Angeng Capsules[J]. Chinese Pharmaceutical Journal,2006,41(22):1741-1744. |
| APA | FANG Liang.,WEI Xiaohui.,HE Qiaojun.,LUO Peihua.,FAN Lingling.,...&SHEN Jingshan.(2006).Studies on Treatment of Menopausal Syndrome with Angeng Capsules.Chinese Pharmaceutical Journal,41(22),1741-1744. |
| MLA | FANG Liang,et al."Studies on Treatment of Menopausal Syndrome with Angeng Capsules".Chinese Pharmaceutical Journal 41.22(2006):1741-1744. |
入库方式： OAI收割
来源：上海药物研究所
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