INVOLVEMENT OF ATTENUATION OF Na^＋ , K ＋ -ATPase ACTIVITY AND DECREMENT OF ENERGY METABOLISM ENZYME EXPRESSION IN THE DEVELOPMENT OF MORPHINE DEPENDENCE
文献类型：期刊论文
| 作者 | WU Zhaoqiu; CHEN Xiaolan; LU Gang; CHEN Jie; CHI Zhiqiang ; LIU Jinggen
|
| 刊名 | Chinese Journal of Drug Dependence
 |
| 出版日期 | 2006 |
| 卷号 | 15期号:3页码:165-167 |
| 关键词 | Na^＋,K^＋-ATPase酶 hippocampus glucose morphine dependence Na^＋ , K^＋ - ATPase learning and memory |
| ISSN号 | 1007-9718 |
| 其他题名 | 慢性吗啡引起的抑制海马神经元 Na^＋,K^＋-ATPase活性和降低能量代谢酶的表达可能参与小鼠吗啡依赖的形成 |
| 文献子类 | Review |
| 英文摘要 | Accumulating evidence has demonstrated that the hippocampus contributes to the development of opioid dependence. However, the mechanisms underlying the role of the hippocampus in opioid dependence are to be determined. Here, we demonstrated that chronic exposure of mice to morphine for 10 days resulted in a significant attenuation of Na^＋ , K^＋ - ATPase activity via upregulation of cAMP/PKA signal pathway. Given the previous findings that the depolarization of neurons induced by impairment of Na^＋, K^＋ - ATPase activity is involved in the development of opioid dependence, these findings suggest that diminution of Na^＋ , K^＋ - ATPase mediated by up - regulated cAMP/PKA cascade may be a potential mechanism underlying opioid dependence. In addition, we also found that chronic morphine treatment led to a remarkable down -regulation of the protein level of three energy metabolism enzymes. The failure of conversion of glucose into ATP was also observed in the chronic morphine- treated but not acute morphine- treated mice hippocampus. Intra- hippocampal injection of D - glucose but not non - metabolizable sugar 3 - O - methyl - glucose prior to morphine administration significantly suppressed naloxone - precipitated withdrawal jumping in acute morphine- treated mice. However, intra - hippocampal injection of glucose was unable to suppress naloxone - precipitated withdrawal jumping in chronic morphine - treated mice. These results demonstrated that the down- regulations of the hippocampal energy metabolism protein expression and impairment of glucose metabolism were also involved in the development of morphine dependence. |
| 资助项目 | 国家重点基础研究发展计划（973计划）资助项目[00000000] |
| WOS研究方向 | Public, Environmental & Occupational Health ; Neurosciences & Neurology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2447066 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268204]  |
| 专题 | 院士及顾问专家 药理学第二研究室 |
| 作者单位 | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | WU Zhaoqiu,CHEN Xiaolan,LU Gang,等. INVOLVEMENT OF ATTENUATION OF Na^＋ , K ＋ -ATPase ACTIVITY AND DECREMENT OF ENERGY METABOLISM ENZYME EXPRESSION IN THE DEVELOPMENT OF MORPHINE DEPENDENCE[J]. Chinese Journal of Drug Dependence,2006,15(3):165-167. |
| APA | WU Zhaoqiu,CHEN Xiaolan,LU Gang,CHEN Jie,CHI Zhiqiang,&LIU Jinggen.(2006).INVOLVEMENT OF ATTENUATION OF Na^＋ , K ＋ -ATPase ACTIVITY AND DECREMENT OF ENERGY METABOLISM ENZYME EXPRESSION IN THE DEVELOPMENT OF MORPHINE DEPENDENCE.Chinese Journal of Drug Dependence,15(3),165-167. |
| MLA | WU Zhaoqiu,et al."INVOLVEMENT OF ATTENUATION OF Na^＋ , K ＋ -ATPase ACTIVITY AND DECREMENT OF ENERGY METABOLISM ENZYME EXPRESSION IN THE DEVELOPMENT OF MORPHINE DEPENDENCE".Chinese Journal of Drug Dependence 15.3(2006):165-167. |
入库方式： OAI收割
来源：上海药物研究所
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