Design, synthesis and insulin-sensitizing activity of indole derivatives
文献类型：期刊论文
| 作者 | TANG Lei1; YANG Yushe2 ; JI Ruyun2
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2006 |
| 卷号 | 41期号:3页码:225-229 |
| 关键词 | insulin-sensitizing activity 3T3-L1 cell type 2 diabetes |
| ISSN号 | 0513-4870 |
| 其他题名 | 吲哚衍生物的设计、合成及胰岛素增敏活性 |
| 文献子类 | Article |
| 英文摘要 | Aim To design and synthesize compounds with insulin-sensitizing activity. Methods Using association principle of drug design, ten title compounds were designed and synthesized on the basis of known compounds with insulin-sensitizing activity, and their insulin-sensitizing activity were evaluated on 3T3-LI pre-adipocyte cells. Results One of the synthesized compounds showed strong insulin-sensitizing activity in vitro. Conclusion This compound may possess good sugar-lowering activity, and will be chosen for further hypoglycemic evaluation in vivo. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2353704 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268270]  |
| 专题 | 药物化学研究室 |
| 作者单位 | 1.School of Pharmacy, Guiyang Medical College, Guiyang, Guizhou 550004, China.; 2.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | TANG Lei,YANG Yushe,JI Ruyun. Design, synthesis and insulin-sensitizing activity of indole derivatives[J]. Acta Pharmaceutica Sinica,2006,41(3):225-229. |
| APA | TANG Lei,YANG Yushe,&JI Ruyun.(2006).Design, synthesis and insulin-sensitizing activity of indole derivatives.Acta Pharmaceutica Sinica,41(3),225-229. |
| MLA | TANG Lei,et al."Design, synthesis and insulin-sensitizing activity of indole derivatives".Acta Pharmaceutica Sinica 41.3(2006):225-229. |
入库方式： OAI收割
来源：上海药物研究所
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