Current status of studies on Acyl-CoA: Cholesterol Acyltransferase (ACAT) inhibitors
文献类型:期刊论文
作者 | Din Derong; Shen Jingkang |
刊名 | Chinese Journal New Drugs
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出版日期 | 2005 |
卷号 | 14期号:4页码:396-400 |
关键词 | ACAT inhibitor atherosclerosis cholesterol-lowering lipid-lowering |
ISSN号 | 1003-3734 |
其他题名 | ACAT抑制剂的研究进展 |
文献子类 | Review |
英文摘要 | Acyl-CoA: Cholesterol Acyltransferase (ACAT) catalyzes cholesterol esterification, regulates intracellular free cholesterol levels, and promotes both cholesterol absorption in the small in-testine and assembly of low-density lipoprotein (LDL) in the liver. ACAT inhibitors demonstrate cholesterol-lowering and antiatherosclerotic activities by blocking intestinal absorption of dietary cholesterol , inhibiting hepatic secretion of LDL, and preventing the formation of foam cells in the arterial wall. ACAT inhibitors have been regarded as potential lipid-lowering therapies and anti-atherosclerotic therapies. This review presents the current status of ACAT inhibitors in recent years. |
WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
语种 | 中文 |
CSCD记录号 | CSCD:1931433 |
源URL | [http://119.78.100.183/handle/2S10ELR8/268293] ![]() |
专题 | 药物化学研究室 |
作者单位 | Department of Medicinal Chemistry , Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China. |
推荐引用方式 GB/T 7714 | Din Derong,Shen Jingkang. Current status of studies on Acyl-CoA: Cholesterol Acyltransferase (ACAT) inhibitors[J]. Chinese Journal New Drugs,2005,14(4):396-400. |
APA | Din Derong,&Shen Jingkang.(2005).Current status of studies on Acyl-CoA: Cholesterol Acyltransferase (ACAT) inhibitors.Chinese Journal New Drugs,14(4),396-400. |
MLA | Din Derong,et al."Current status of studies on Acyl-CoA: Cholesterol Acyltransferase (ACAT) inhibitors".Chinese Journal New Drugs 14.4(2005):396-400. |
入库方式: OAI收割
来源:上海药物研究所
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