Current status of studies on Acyl-CoA: Cholesterol Acyltransferase (ACAT) inhibitors
文献类型：期刊论文
| 作者 | Din Derong; Shen Jingkang |
| 刊名 | Chinese Journal New Drugs
 |
| 出版日期 | 2005 |
| 卷号 | 14期号:4页码:396-400 |
| 关键词 | ACAT inhibitor atherosclerosis cholesterol-lowering lipid-lowering |
| ISSN号 | 1003-3734 |
| 其他题名 | ACAT抑制剂的研究进展 |
| 文献子类 | Review |
| 英文摘要 | Acyl-CoA: Cholesterol Acyltransferase (ACAT) catalyzes cholesterol esterification, regulates intracellular free cholesterol levels, and promotes both cholesterol absorption in the small in-testine and assembly of low-density lipoprotein (LDL) in the liver. ACAT inhibitors demonstrate cholesterol-lowering and antiatherosclerotic activities by blocking intestinal absorption of dietary cholesterol , inhibiting hepatic secretion of LDL, and preventing the formation of foam cells in the arterial wall. ACAT inhibitors have been regarded as potential lipid-lowering therapies and anti-atherosclerotic therapies. This review presents the current status of ACAT inhibitors in recent years. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:1931433 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268293]  |
| 专题 | 药物化学研究室 |
| 作者单位 | Department of Medicinal Chemistry , Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Din Derong,Shen Jingkang. Current status of studies on Acyl-CoA: Cholesterol Acyltransferase (ACAT) inhibitors[J]. Chinese Journal New Drugs,2005,14(4):396-400. |
| APA | Din Derong,&Shen Jingkang.(2005).Current status of studies on Acyl-CoA: Cholesterol Acyltransferase (ACAT) inhibitors.Chinese Journal New Drugs,14(4),396-400. |
| MLA | Din Derong,et al."Current status of studies on Acyl-CoA: Cholesterol Acyltransferase (ACAT) inhibitors".Chinese Journal New Drugs 14.4(2005):396-400. |
入库方式： OAI收割
来源：上海药物研究所
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