Research progress in regulators of G-protein signaling as new central nervous system drug targets
文献类型：期刊论文
| 作者 | Yin Linlin; Zhu Xingzu |
| 刊名 | Chinese Pharmacological Bulletin
 |
| 出版日期 | 2005 |
| 卷号 | 21期号:9页码:1041-1045 |
| 关键词 | GPCR RGS GPGR RGS central nervous system drug targets |
| ISSN号 | 1001-1978 |
| 其他题名 | G蛋白信号调节蛋白作为中枢神经系统药物新靶点研究进展 |
| 文献子类 | Review |
| 英文摘要 | G-protein-coupled receptors （GPCRs） are major targets for drug discovery. The regulator of G- protein signaling （RGS） proteins is a recently identified protein family, which strongly modulates the activity of G proteins. RGS proteins accelerate the deactivation of G proteins to reduce （;PCR signaling; however, some also have an effector function and transmit signals. Combining GPCR agonists with RGS inhibitorsshould potentiate responses and markedly increase the regional specificity of agonist. In the central nervous system, RGS proteins have unique tissue distributions and are strongly regulated by signal transduction events. Thus the diversity of RGS makes them attractive targets for pharmacotherapy of neurological disorders. |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2152128 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268312]  |
| 专题 | 药理学第二研究室 |
| 作者单位 | Shanghai Institute of Materia Medico., Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Yin Linlin,Zhu Xingzu. Research progress in regulators of G-protein signaling as new central nervous system drug targets[J]. Chinese Pharmacological Bulletin,2005,21(9):1041-1045. |
| APA | Yin Linlin,&Zhu Xingzu.(2005).Research progress in regulators of G-protein signaling as new central nervous system drug targets.Chinese Pharmacological Bulletin,21(9),1041-1045. |
| MLA | Yin Linlin,et al."Research progress in regulators of G-protein signaling as new central nervous system drug targets".Chinese Pharmacological Bulletin 21.9(2005):1041-1045. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。