Advances in the pharmacology of cyclooxygenase
文献类型：期刊论文
| 作者 | Zhang Weiyu; Zhu Xingzu |
| 刊名 | Chinese Bulletin of Life Sciences
 |
| 出版日期 | 2005 |
| 卷号 | 17期号:3页码:230-235 |
| 关键词 | cyclooxygenase prostaglandins inflammation neurodegenerative disease cardiovascular disease cancer non-steroidal anti-inflammatory drugs |
| ISSN号 | 1004-0374 |
| 其他题名 | 环加氧酶及其药理学研究进展 |
| 文献子类 | Article |
| 英文摘要 | Cyclooxygenase (COX), a rate-limited enzyme in arachidonic acid metabolic pathways, can catalyse the synthesis of cyclic endoperoxides from arachidonic acid to form prostaglandins (PGs). Two cyclooxygenase isoforms have been identified and referred to as constitutive COX-1 and inducible COX-2. According to a popular hypothesis, COX-1 generates "good" prostaglandins for physiological housekeeping functions, while COX-2 forms the "bad" prostaglandins responsible for inflammatory symptoms. However, recent data show that the biological functions of prostanoids formed by the two enzymes are much more complex and interrelated than previously appreciated. The objective of the article is to provide an overview of recent developments in the field about the role of COX in various diseases, and to discuss the feasibility as a potential target for therapeutic treatment. |
| 资助项目 | 上海市生命科学重大基础研究项目[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:1966835 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268345]  |
| 专题 | 药理学第二研究室 |
| 作者单位 | Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of CAS, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Zhang Weiyu,Zhu Xingzu. Advances in the pharmacology of cyclooxygenase[J]. Chinese Bulletin of Life Sciences,2005,17(3):230-235. |
| APA | Zhang Weiyu,&Zhu Xingzu.(2005).Advances in the pharmacology of cyclooxygenase.Chinese Bulletin of Life Sciences,17(3),230-235. |
| MLA | Zhang Weiyu,et al."Advances in the pharmacology of cyclooxygenase".Chinese Bulletin of Life Sciences 17.3(2005):230-235. |
入库方式： OAI收割
来源：上海药物研究所
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