Down regulation of cyclooxygenase-2 is involved in delayed neuroprotection by ischemic preconditioning in rats
文献类型：期刊论文
| 作者 | Xiao Liang; Zhao Feili; Zhu Xingzu |
| 刊名 | Acta Pharmacologica Sinica
 |
| 出版日期 | 2005 |
| 卷号 | 26期号:4页码:441-446 |
| 关键词 | ischemic preconditioning brain ischemia prostaglandins cyclooxygenase-2 |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7254.2005.00064.x |
| 文献子类 | Article |
| 英文摘要 | Aim: To examine whether the prostaglandins (PGs) pathway is involved in triggering delayed neuroprotection by ischemic preconditioning (IPC) and evaluate the effects of IPC on cyclooxygenase-2 (COX-2) expression following focal cerebral ischemia and reperfusion in rats. Methods: IPC was induced by 10 min of saline infusion into the left internal carotid artery with the right common carotid artery clamped at the same time. Middle cerebral artery occlusion (MCAO) and reperfusion model was produced using intraluminal filament method. Results: IPC 48 h prior to MCAO significantly reduced infarct area as compared with MCAO alone. A nonselective inhibitor of COX indomethacin (3 mg/kg ip) applied 1 h prior to or 1 h after IPC failed to affect its protective effects. IPC had no direct effect on the cortex COX-2 mRNA and protein expression 72 h later, but decreased the expression of COX-2 mRNA and protein following ischemia and reperfusion insult. Conclusion: PGs pathways was not involved in triggering delayed neuroprotection by IPC, and IPC induced down-regulation of COX-2 following focal cerebral ischemia and reperfusion in rats in vivo. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 英语 |
| CSCD记录号 | CSCD:2000109 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268361]  |
| 专题 | 药理学第二研究室 |
| 作者单位 | Department of Pharmacology II, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, ShangHai 201203, China. |
| 推荐引用方式 GB/T 7714 | Xiao Liang,Zhao Feili,Zhu Xingzu. Down regulation of cyclooxygenase-2 is involved in delayed neuroprotection by ischemic preconditioning in rats[J]. Acta Pharmacologica Sinica,2005,26(4):441-446. |
| APA | Xiao Liang,Zhao Feili,&Zhu Xingzu.(2005).Down regulation of cyclooxygenase-2 is involved in delayed neuroprotection by ischemic preconditioning in rats.Acta Pharmacologica Sinica,26(4),441-446. |
| MLA | Xiao Liang,et al."Down regulation of cyclooxygenase-2 is involved in delayed neuroprotection by ischemic preconditioning in rats".Acta Pharmacologica Sinica 26.4(2005):441-446. |
入库方式： OAI收割
来源：上海药物研究所
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