Adenosine/dopamine receptor dimerization in basal ganglia: implications for the pharmacology
文献类型：期刊论文
| 作者 | Sun Wanchun; Zhu Xingzu |
| 刊名 | Chinese Bulletin of Life Sciences
 |
| 出版日期 | 2004 |
| 卷号 | 16期号:4页码:193-199 |
| 关键词 | G protein coupled receptor receptor heteromeric complex receptor-receptor interaction trafficking |
| ISSN号 | 1004-0374 |
| 其他题名 | 基底神经节中多巴胺和腺苷受体二聚化及其药理学意义 |
| 文献子类 | Review |
| 英文摘要 | Recently, many studies have revealed that G Protein-coupled receptors (GPCRs) exist as dimmers, which may be present homo- or heterodimers/oligomers. The anatomical localizations indicate that Al receptor and Dl receptor coexist in strionigro-strioentopeduncular neurons, and A2a receptor and D2 receptor coexist in striopallidals neurons. The heteromeric complexes of A1/D1> A2a/D2 receptor provided the molecular basis for the functional interactions of Al/Dl and A2a/D2 receptor. The antagonistic receptor-receptor intramembrane interactions may offer new therapeutic leads for Parkinson's disease, Huntington's disease, schizophrenia and drug addiction. |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:1605704 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268405]  |
| 专题 | 药理学第二研究室 |
| 作者单位 | Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of CAS, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Sun Wanchun,Zhu Xingzu. Adenosine/dopamine receptor dimerization in basal ganglia: implications for the pharmacology[J]. Chinese Bulletin of Life Sciences,2004,16(4):193-199. |
| APA | Sun Wanchun,&Zhu Xingzu.(2004).Adenosine/dopamine receptor dimerization in basal ganglia: implications for the pharmacology.Chinese Bulletin of Life Sciences,16(4),193-199. |
| MLA | Sun Wanchun,et al."Adenosine/dopamine receptor dimerization in basal ganglia: implications for the pharmacology".Chinese Bulletin of Life Sciences 16.4(2004):193-199. |
入库方式： OAI收割
来源：上海药物研究所
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