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Impact of ABCB1 gene polymorphism on opioid dependence and analgesic tolerance

文献类型：期刊论文

作者Gan Chenling1; Chen Zhongguo2; He Ling1; Liu Jinggen2
刊名Chinese Pharmacological Bulletin
出版日期2014
卷号30期号:8页码:1055-1058
关键词ABCB1 3435C>T drug dependence ABCB1 gene polymorphism 3435C >T analgesic tolerance MMT
ISSN号1001-1978
其他题名ABCB1基因多态性对阿片类药物依赖和镇痛耐受的影响及机制
文献子类Review
英文摘要Drug dependence has been a hot topic in neuroscience research due to its complicated pathogenesis. Recently, huge scientific efforts have been continuously put into understanding the association between drug dependence and polymorphism in ATP-binding cassette subfamily B member 1 transporter (ABCB1) gene, especially a mutation in exon 26 at position 3435 (3435C > T). This article reviews the relationship between opioid dependence and analgesic tolerance and ABCB1 gene polymorphism,which will shed light on the underlying mechanisms of drug dependence and optimal MMT programs for individuals.
资助项目国家重点基础研究发展计划(973计划)资助项目[00000000] ; 国家十二五新药创制科技重大专项基金资助项目[00000000] ; 十二五国家科技支撑计划重大专项资助[00000000] ; 国家自然科学基金[00000000] ; 上海市科学技术委员会基金项目[00000000]
WOS研究方向General & Internal Medicine ; Neurosciences & Neurology ; Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:5205464
源URL[http://119.78.100.183/handle/2S10ELR8/269321]  
专题药理学第二研究室
作者单位1.Dept of Pharmacology, China Pharmaceutical University, Nanjing, Jiangsu 210009, China.;
2.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式
GB/T 7714		 Gan Chenling,Chen Zhongguo,He Ling,et al. Impact of ABCB1 gene polymorphism on opioid dependence and analgesic tolerance[J]. Chinese Pharmacological Bulletin,2014,30(8):1055-1058.
APA Gan Chenling,Chen Zhongguo,He Ling,&Liu Jinggen.(2014).Impact of ABCB1 gene polymorphism on opioid dependence and analgesic tolerance.Chinese Pharmacological Bulletin,30(8),1055-1058.
MLA Gan Chenling,et al."Impact of ABCB1 gene polymorphism on opioid dependence and analgesic tolerance".Chinese Pharmacological Bulletin 30.8(2014):1055-1058.

入库方式： OAI收割

来源：上海药物研究所

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