Bioisosteric replacement and its application in drug design
文献类型：期刊论文
| 作者 | Zhang Lei; Liu Hong
|
| 刊名 | Chinese Journal of Medicinal Chemistry
 |
| 出版日期 | 2014 |
| 卷号 | 24期号:3页码:214-230 |
| 关键词 | bioisosteric replacement bioisosterism lead compound drug design structural optimization |
| ISSN号 | 1005-0108 |
| 其他题名 | 等排置换及其在药物分子设计中的应用 |
| 文献子类 | Review |
| 英文摘要 | Bioisosteric replacement is an important and widely-used drug design strategy in the optimization process from hits to drug candidates. In this review, bioisosteric replacement is classified into atom or group replacement, functional group replacement, and ring replacement based on the complexity of the structural moieties to be replaced. The applications of bioisosteric replacement to enhance potency and selectivity, reduce toxicity and side effects, improve pharmacokinetic properties and create patent novelty are demonstrated by specific examples from recent literature. |
| 资助项目 | 国家杰出青年科学基金项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5177077 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269332]  |
| 专题 | 药物化学研究室 药理学第二研究室 |
| 通讯作者 | Liu Hong |
| 作者单位 | Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Zhang Lei,Liu Hong. Bioisosteric replacement and its application in drug design[J]. Chinese Journal of Medicinal Chemistry,2014,24(3):214-230. |
| APA | Zhang Lei,&Liu Hong.(2014).Bioisosteric replacement and its application in drug design.Chinese Journal of Medicinal Chemistry,24(3),214-230. |
| MLA | Zhang Lei,et al."Bioisosteric replacement and its application in drug design".Chinese Journal of Medicinal Chemistry 24.3(2014):214-230. |
入库方式： OAI收割
来源：上海药物研究所
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