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Progress on the molecular mechanisms of synaptic actin rearrangements in regulating morphine withdrawal induced aversive memory formation

文献类型：期刊论文

作者Liu Yao2; Zhou QiXin1; Xu Lin1; Liu JingGen2
刊名Chinese Science Bulletin
出版日期2014
卷号59期号:1页码:15-20
关键词opioid withdrawal synaptic actin rearrangement aversive memory Arc protein AMPA receptor long term depression
ISSN号0023-074X
其他题名突触骨架重塑调控吗啡戒断负性记忆的分子机制进展
文献子类Article
英文摘要The formation of aversive learning and memory attributes to the abnormal addictive behaviors, which leads to long-term adaptations such as synaptic transmission and neuronal architectural plasticity in addiction-related brain regions, and finally causes pathological memory formation. Researches show that the cytoskeletal actin rearrangements play a critical role in synaptic plasticity and memory formation. However, little is known about the molecular mechanisms of actin rearrangements regulated memory. Recently, our research group focused on the study of mechanisms of morphine withdrawal induced aversive memory formation, manifesting the involvement of cytoskeletal actin and its downstream effectors in regulation memory in vivo. This article will discuss the latest progress on the involvement of synaptic structural plasticity in regulating addictive drugs, especially opioid withdrawal induced aversive motivation formation, which would contribute to a better understanding of the molecular foundation of addictive behaviors, and provides us new ideas for addiction research and therapy.
资助项目国家自然科学基金[00000000] ; 国家自然科学基金重大研究计划[00000000] ; 国家重点基础研究发展计划[00000000]
WOS研究方向Science & Technology - Other Topics (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:5061337
源URL[http://119.78.100.183/handle/2S10ELR8/269351]  
专题药理学第二研究室
通讯作者Liu JingGen
作者单位1.Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.
2.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.;
推荐引用方式
GB/T 7714		 Liu Yao,Zhou QiXin,Xu Lin,et al. Progress on the molecular mechanisms of synaptic actin rearrangements in regulating morphine withdrawal induced aversive memory formation[J]. Chinese Science Bulletin,2014,59(1):15-20.
APA Liu Yao,Zhou QiXin,Xu Lin,&Liu JingGen.(2014).Progress on the molecular mechanisms of synaptic actin rearrangements in regulating morphine withdrawal induced aversive memory formation.Chinese Science Bulletin,59(1),15-20.
MLA Liu Yao,et al."Progress on the molecular mechanisms of synaptic actin rearrangements in regulating morphine withdrawal induced aversive memory formation".Chinese Science Bulletin 59.1(2014):15-20.

入库方式： OAI收割

来源：上海药物研究所

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