Annotinolide F and lycoannotines A-I, further Lycopodium alkaloids from Lycopodium annotinum
文献类型：期刊论文
| 作者 | Tang, Yu1; Xiong, Juan1; Zou, Yike2; Wang, Wei3; Huang, Chao1; Zhang, Hai-Yan3 ; Hu, Jin-Feng1
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2017-11 |
| 卷号 | 143页码:1-11 |
| 关键词 | Lycopodium annotinum Lycopodiaceae Lycopodium alkaloids Annotinolide F Lycoannotines |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2017.07.003 |
| 文献子类 | Article |
| 英文摘要 | Seven lycopodine-type (annotinolide F and lycoannotines A-F), two lycodine-type (lycoannotines G and H), and one fawcettimine-type (lycoannotine I) previously undescribed naturally occurring Lycopodium alkaloids together with thirteen known ones were isolated from the whole plant of Lycopodium annotinum. Their structures and absolute configurations were determined by extensive spectroscopic methods, single-crystal X-ray diffraction, chemical transformation, and electronic circular dichroism (ECD) calculations. Among the isolates, annotinolide F, lycoannotines A and B are unusual 7,8-secolycopodane derivatives, and annotinolide F even further possesses a rare 8,5-lactone framework through a lactonization after the C-7/C-8 bond cleavage. Lycoannotine C is an uncommon 8,15-seco lycopodine-type alkaloid, whereas lycoannotine I represents the first example of a naturally occurring C-9/N bond cleavage product of fawcettimine-type alkaloid. Among them, only lycoannotine I was found to show considerable anti-butyrylcholinesterase (anti-BuChE) activity. (C) 2017 Elsevier Ltd. All rights reserved. |
| WOS关键词 | ALZHEIMERS-DISEASE ; ACETYLCHOLINESTERASE ; HUPERZINE |
| 资助项目 | NSFC[21472021] ; National Basic Research Program of China (973 Program)[2013CB530700] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000413128900001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272435]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Hu, Jin-Feng |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Nat Prod Chem, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; 2.Univ Penn, Dept Chem, 231 S 34 St, Philadelphia, PA 19104 USA; 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Yu,Xiong, Juan,Zou, Yike,et al. Annotinolide F and lycoannotines A-I, further Lycopodium alkaloids from Lycopodium annotinum[J]. PHYTOCHEMISTRY,2017,143:1-11. |
| APA | Tang, Yu.,Xiong, Juan.,Zou, Yike.,Wang, Wei.,Huang, Chao.,...&Hu, Jin-Feng.(2017).Annotinolide F and lycoannotines A-I, further Lycopodium alkaloids from Lycopodium annotinum.PHYTOCHEMISTRY,143,1-11. |
| MLA | Tang, Yu,et al."Annotinolide F and lycoannotines A-I, further Lycopodium alkaloids from Lycopodium annotinum".PHYTOCHEMISTRY 143(2017):1-11. |
入库方式： OAI收割
来源：上海药物研究所
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