The neuroprotective effect of memantine on methamphetamine-induced cognitive deficits
文献类型：期刊论文
| 作者 | Long, Jian-Dong1,2; Liu, Yao3; Jiao, Dong-Liang3; Wang, Yu-Jun1,2 ; Zan, Gui-Ying1,2; Ju, Yun-Yue3; Zhao, Min3; Liu, Jing-Gen1,2
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| 刊名 | BEHAVIOURAL BRAIN RESEARCH
 |
| 出版日期 | 2017-04-14 |
| 卷号 | 323页码:133-140 |
| 关键词 | Methamphetamine Memantine Cognitive deficits Apoptosis Prefrontal cortex |
| ISSN号 | 0166-4328 |
| DOI | 10.1016/j.bbr.2017.01.042 |
| 文献子类 | Article |
| 英文摘要 | Repeated exposure to methamphetamine (METH) can cause severe neurotoxicity to the cortical neurons. In the present study, we investigated the effect of METH on cognitive function deficits, and determined the neuroprotective effects of memantine (MEM) on memory impairment induced by METH. The protein levels of Bcl-2 and cleaved caspase-3 in prefrontal cortex (PFC) were further examined to exploring the underlying mechanism. We found that repeated METH administration impaired long term (24 h) memory retention without affecting short term (5 min) memory retention. Co-administration of MEM with METH before training session significantly improved METH-induced cognitive function. METH significantly decreased expression level of Bcl-2 and increased expression level of cleaved caspase-3 in the PFC. The changes can be prevented by MEM pretreatment. Thus, these results demonstrated that MEM pretreatment reversed METH-induced changes of protein levels of apoptotic-related gene, and produced protective effects against METH-induced cognitive deficits, suggesting the effectiveness of MEM may be due to its anti-apoptotic activity. (C) 2017 Elsevier B.V. All rights reserved. |
| WOS关键词 | OBJECT RECOGNITION ; INDUCED NEUROTOXICITY ; PREFRONTAL CORTEX ; APOPTOSIS ; RATS ; MITOCHONDRIA ; MECHANISMS ; ADDICTION ; MEMORY ; CELLS |
| 资助项目 | National Natural Science Foundation of China[81271468] ; National Natural Science Foundation of China[81130087] ; National Natural Science Foundation of China[91232716] ; Shanghai Municipal Health and Family Planning Commission joint research project[2014ZYJB0002] ; Ministry of Science and Technology of China[2013CB835100] ; China Post-doctoral Science Foundation[2014M561482] |
| WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000397369100016 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272699]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Zhao, Min |
| 作者单位 | 1.Chinese Acad Sci, Collaborat Innovat Ctr Brain Sci, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai 200030, Peoples R China |
| 推荐引用方式 GB/T 7714 | Long, Jian-Dong,Liu, Yao,Jiao, Dong-Liang,et al. The neuroprotective effect of memantine on methamphetamine-induced cognitive deficits[J]. BEHAVIOURAL BRAIN RESEARCH,2017,323:133-140. |
| APA | Long, Jian-Dong.,Liu, Yao.,Jiao, Dong-Liang.,Wang, Yu-Jun.,Zan, Gui-Ying.,...&Liu, Jing-Gen.(2017).The neuroprotective effect of memantine on methamphetamine-induced cognitive deficits.BEHAVIOURAL BRAIN RESEARCH,323,133-140. |
| MLA | Long, Jian-Dong,et al."The neuroprotective effect of memantine on methamphetamine-induced cognitive deficits".BEHAVIOURAL BRAIN RESEARCH 323(2017):133-140. |
入库方式： OAI收割
来源：上海药物研究所
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