H-1, C-13 and N-15 backbone and side-chain resonance assignments of the ZnF-UBP domain of USP20/VDU2
文献类型：期刊论文
| 作者 | Yang, Yuanyuan; Wen, Yi; Zhang, Naixia
|
| 刊名 | BIOMOLECULAR NMR ASSIGNMENTS
 |
| 出版日期 | 2017-04 |
| 卷号 | 11期号:1页码:91-93 |
| 关键词 | Deubiquitinase USP20 ZnF-UBP domain NMR |
| ISSN号 | 1874-2718 |
| DOI | 10.1007/s12104-017-9726-y |
| 文献子类 | Article |
| 英文摘要 | Deubiquitinase USP20/VDU2 has been identified as a regulator of multiple proteins including hypoxia-inducible factor (HIF)-1 alpha, beta 2-adrenergic receptor, and tumor necrosis factor receptor associated factor 6 etc. It contains four structural domains, including an N-terminal zinc-finger ubiquitin binding domain (ZnF-UBP) that potentially helps USP20 to recruit its ubiquitin substrates. Here we report the H-1, C-13 and N-15 backbone and side-chain resonance assignments of the ZnF-UBP domain of USP20/VDU2. The BMRB accession number is 26901. The secondary structural elements predicted from the NMR data reveal a global fold consisting of three alpha-helices and four beta-strands. The complete assignments can be used to explore the protein dynamics of the USP20 ZnF-UBP and its interactions with monoubiquitin and ubiquitin chains. |
| WOS关键词 | LINDAU TUMOR-SUPPRESSOR ; UBIQUITIN ; DEUBIQUITINASES ; PROTEIN ; PATHWAYS ; BINDING ; CANCER |
| 资助项目 | National Natural Science Foundation of China[21272246] ; National Natural Science Foundation of China[31300608] ; National Key Basic Research Program of China[2013CB910900] |
| WOS研究方向 | Biophysics ; Spectroscopy |
| 语种 | 英语 |
| WOS记录号 | WOS:000396133800018 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272728]  |
| 专题 | 分析化学研究室 |
| 通讯作者 | Wen, Yi; Zhang, Naixia |
| 作者单位 | Chinese Acad Sci, CAS Key Lab Receptor Res, Dept Analyt Chem, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Yuanyuan,Wen, Yi,Zhang, Naixia. H-1, C-13 and N-15 backbone and side-chain resonance assignments of the ZnF-UBP domain of USP20/VDU2[J]. BIOMOLECULAR NMR ASSIGNMENTS,2017,11(1):91-93. |
| APA | Yang, Yuanyuan,Wen, Yi,&Zhang, Naixia.(2017).H-1, C-13 and N-15 backbone and side-chain resonance assignments of the ZnF-UBP domain of USP20/VDU2.BIOMOLECULAR NMR ASSIGNMENTS,11(1),91-93. |
| MLA | Yang, Yuanyuan,et al."H-1, C-13 and N-15 backbone and side-chain resonance assignments of the ZnF-UBP domain of USP20/VDU2".BIOMOLECULAR NMR ASSIGNMENTS 11.1(2017):91-93. |
入库方式： OAI收割
来源：上海药物研究所
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