Cerebral metabolic changes in a depression-like rat model of chronic forced swimming studied by ex vivo high resolution (1)H magnetic resonance spectroscopy
文献类型：期刊论文
| 作者 | Li, Chun-Xia2,3; Wang, Yaqiang2,3; Gao, Hongchang4; Pan, Wen-Ju2,3; Xiang, Yun1,2,3; Huang, Mingming2,3; Lei, Hao2 |
| 刊名 | NEUROCHEMICAL RESEARCH
 |
| 出版日期 | 2008-11 |
| 卷号 | 33期号:11页码:2342-2349 |
| 关键词 | depression chronic forced swimming NMR glutamate metabolism rat |
| ISSN号 | 0364-3190 |
| DOI | 10.1007/s11064-008-9739-0 |
| 文献子类 | Article |
| 英文摘要 | Many previous in vivo (1)H magnetic resonance spectroscopy (MRS) studies have shown that patients with major depressive disorder (MDD) are associated with perturbations of cerebral metabolism of neurotransmitters glutamate (Glu) and gamma-aminobutyric acid (GABA). In this study, we investigated the changes of cerebral metabolism in a depression-like rat model of chronic forced swimming stress (CFSS). The aims are to further understand the pathophysiological mechanisms underlying CFSS treatment, and to further establish the face and predictive validity of the CFSS model. The results showed that, relative to control, the CFSS rats had significantly reduced Glu, taurine and glutamate + glutamine (Glx) levels in the PFC, and significantly reduced N-acetyl aspartate (NAA) level, Glu level and Glu/GABA ratio in the hippocampus. Taking together, these results suggest that CFSS treatment can induce region-specific changes in the metabolism of Glu. The CFSS model might be used to study antidepressants specifically targeting the central glutamatergic system. |
| WOS关键词 | GAMMA-AMINOBUTYRIC-ACID ; STRESS-INDUCED CHANGES ; MAJOR DEPRESSION ; PREFRONTAL CORTEX ; ELECTROCONVULSIVE-THERAPY ; HIPPOCAMPAL NEUROGENESIS ; ANTIDEPRESSANT TREATMENT ; GLUTAMATE ; BEHAVIOR ; MEMORY |
| 资助项目 | Chinese Academy of Science key project[kjcx2-sw-h12-03] ; Chinese Ministry of Science and Technology[2006CB705607] ; Chinese Ministry of Science and Technology[2006AA02Z4A1] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000259483300022 |
| 出版者 | SPRINGER/PLENUM PUBLISHERS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272769]  |
| 专题 | 分析化学研究室 |
| 通讯作者 | Lei, Hao |
| 作者单位 | 1.Jianghan Univ, Sch Life Sci & Med, Wuhan 430056, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China; 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Analyt Chem Lab, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Chun-Xia,Wang, Yaqiang,Gao, Hongchang,et al. Cerebral metabolic changes in a depression-like rat model of chronic forced swimming studied by ex vivo high resolution (1)H magnetic resonance spectroscopy[J]. NEUROCHEMICAL RESEARCH,2008,33(11):2342-2349. |
| APA | Li, Chun-Xia.,Wang, Yaqiang.,Gao, Hongchang.,Pan, Wen-Ju.,Xiang, Yun.,...&Lei, Hao.(2008).Cerebral metabolic changes in a depression-like rat model of chronic forced swimming studied by ex vivo high resolution (1)H magnetic resonance spectroscopy.NEUROCHEMICAL RESEARCH,33(11),2342-2349. |
| MLA | Li, Chun-Xia,et al."Cerebral metabolic changes in a depression-like rat model of chronic forced swimming studied by ex vivo high resolution (1)H magnetic resonance spectroscopy".NEUROCHEMICAL RESEARCH 33.11(2008):2342-2349. |
入库方式： OAI收割
来源：上海药物研究所
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