Immunosuppressive pregnane glycosides from Periploca sepium and Periploca forrestii
文献类型：期刊论文
| 作者 | Feng, Jiaquan1; Zhang, Rujun1; Zhou, Yu2 ; Chen, Zhenhua1; Tang, Wei2; Liu, Qunfang1; Zuo, Jian-Ping2; Zhao, Weimin1
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2008-11 |
| 卷号 | 69期号:15页码:2716-2723 |
| 关键词 | Periploca sepium Periploca forrestii Asclepiadaceae Immunosuppressive Pregnane glycoside |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2008.08.015 |
| 文献子类 | Article |
| 英文摘要 | Nine pregnane glycosides containing peroxy functions in their sugar moieties (1-5 and 11-14), five oligosaccharides (6-10), six pregnane glycosides (15-20), and five cardiac glycosides (21-25) were isolated from the root barks of Periploca sepium Bge. (Asclepiadaceae) and the roots of Periploca forrestii Schltr. (Asclepiadaceae), two traditional Chinese medicines used for the treatment of rheumatoid arthritis. Among them, 1-8 are hitherto unknown. Their structures were characterized on the basis of spectroscopic analyses. In pharmacological testing, compounds 1-5 and 11-14 were found to exhibit inhibitory activity against the proliferation of T lymphocyte in vitro with IC50 values ranging from 0.29 mu M to 1.97 mu M, while the other components showed no significant inhibitory activity. (C) 2008 Elsevier Ltd. All rights reserved. |
| WOS关键词 | CRUDE DRUG WUJIAPI ; T-CELL-ACTIVATION ; BEI-WUJIAPI ; CHEMICAL-CONSTITUENTS ; ANTITUMOR FRACTION ; STEROIDAL GLYCOSIDES ; ROOT-BARKS ; CARDENOLIDES ; AGENTS ; BGE |
| 资助项目 | National Natural Science Foundation of China[20672124] ; Science and Technology Commission of Shanghai Municipality[06DZ19721] ; Shanghai Institute of Materia Medica, Chinese Academy of Sciences[06G604J026] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000261228000009 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272771]  |
| 专题 | 药理学第一研究室 天然药物化学研究室 |
| 通讯作者 | Zuo, Jian-Ping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab New Drug Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Feng, Jiaquan,Zhang, Rujun,Zhou, Yu,et al. Immunosuppressive pregnane glycosides from Periploca sepium and Periploca forrestii[J]. PHYTOCHEMISTRY,2008,69(15):2716-2723. |
| APA | Feng, Jiaquan.,Zhang, Rujun.,Zhou, Yu.,Chen, Zhenhua.,Tang, Wei.,...&Zhao, Weimin.(2008).Immunosuppressive pregnane glycosides from Periploca sepium and Periploca forrestii.PHYTOCHEMISTRY,69(15),2716-2723. |
| MLA | Feng, Jiaquan,et al."Immunosuppressive pregnane glycosides from Periploca sepium and Periploca forrestii".PHYTOCHEMISTRY 69.15(2008):2716-2723. |
入库方式： OAI收割
来源：上海药物研究所
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