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Cytotoxic Cucurbitane-Type Triterpenoids from Elaeocarpus hainanensis

文献类型：期刊论文

作者Meng, Dahai1,2; Qiang, Shigao1,2; Lou, Liguang2; Zhao, Weimin2
刊名PLANTA MEDICA
出版日期2008-11
卷号74期号:14页码:1741-1744
关键词Elaeocarpus hainanensis Elaeocarpaceae cucurbitane triterpenoids cytotoxicity
ISSN号0032-0943
DOI10.1055/s-2008-1081356
文献子类Article
英文摘要Bioassay-guided fractionation of the Crude extract of Elaeocarpus hainanensis (Elaeocarpaceae), using the proliferation of non-small cell lung cancer A549/ATCC and human hepatocellular carcinoma BEL-7402 cells as a monitor, led to the isolation of ten cu-curbitane-type triterpenoids, including three new compounds (1 - 3) and seven known compounds (4- 10). Their Structures were determined on the basis of spectroscopic analyses, chemical methods, and comparison with spectroscopic data in literature. The two known Compounds, curcurbitacins D (5) and 1 (10) were found to exhibit the strongest cytotoxicity against A549/ATCC and BEL-7402 cells in vitro with IC50 values of less than I mu M.
WOS关键词RECEPTOR-BINDING AFFINITY ; INDOLIZIDINE ALKALOIDS ; WILBRANDIA-EBRACTEATA ; GLYCOSIDES ; ROSACEAE ; GRANDIS ; LEAVES
资助项目National High-tech R D Program[2006AA020602] ; Chinese Academy of Sciences[06G8031014] ; Science and Technology Commission of Shanghai Municipality[06DZ22028]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种英语
WOS记录号WOS:000261573500011
出版者GEORG THIEME VERLAG KG
源URL[http://119.78.100.183/handle/2S10ELR8/272772]  
专题药理学第一研究室
天然药物化学研究室
通讯作者Zhao, Weimin
作者单位1.Chinese Acad Sci, Grad Sch, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Meng, Dahai,Qiang, Shigao,Lou, Liguang,et al. Cytotoxic Cucurbitane-Type Triterpenoids from Elaeocarpus hainanensis[J]. PLANTA MEDICA,2008,74(14):1741-1744.
APA Meng, Dahai,Qiang, Shigao,Lou, Liguang,&Zhao, Weimin.(2008).Cytotoxic Cucurbitane-Type Triterpenoids from Elaeocarpus hainanensis.PLANTA MEDICA,74(14),1741-1744.
MLA Meng, Dahai,et al."Cytotoxic Cucurbitane-Type Triterpenoids from Elaeocarpus hainanensis".PLANTA MEDICA 74.14(2008):1741-1744.

入库方式： OAI收割

来源：上海药物研究所

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