Metabonomic profiling of renal cell carcinoma: High-resolution proton nuclear magnetic resonance spectroscopy of human serum with multivariate data analysis
文献类型：期刊论文
| 作者 | Gao, Hongchang2; Dong, Baijun1; Liu, Xia2 ; Xuan, Hanqing1; Huang, Yiran1; Lin, Donghai2
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| 刊名 | ANALYTICA CHIMICA ACTA
 |
| 出版日期 | 2008-08-29 |
| 卷号 | 624期号:2页码:269-277 |
| 关键词 | proton nuclear magnetic resonance metabonomics pattern recognition carcinoma renal cell |
| ISSN号 | 0003-2670 |
| DOI | 10.1016/j.aca.2008.06.051 |
| 文献子类 | Article |
| 英文摘要 | Metabonomic profiling using proton nuclear magnetic resonance ((1)H NMR) spectroscopy and multivariate data analysis of human serum samples was used to characterize metabolic profiles in renal cell carcinoma (RCC). We found distinct, easily detectable differences between (a) RCC patients and healthy humans, (b) RCC patients with metastases and without metastases, and (c) RCC patients before and after nephrectomy Compared to healthy human serum, RCC serum had higher levels of lipid (mainly very low-density lipoproteins), isoleucine, leucine, lactate, alanine, N-acetylglycoproteins, pyruvate, glycerol, and unsaturated lipid, together with lower levels of acetoacetate, glutamine, phosphatidylcholine/choline, trimethylamine-N-oxide, and glucose. This pattern was somewhat reversed after nephrectomy. Altered metabolite concentrations are most likely the result of the cells switching to glycolysis to maintain energy homeostasis following the loss of ATP caused by impaired TCA cycle in RCC. Serum NMR spectra combined with principal component analysis techniques offer an efficient, convenient way of depicting tumour biochemistry and stratifying tumours under different pathophysiological conditions. it may be able to assist early diagnosis and postoperative surveillance of human malignant diseases using single blood samples. (c) 2008 Elsevier B.V. All rights reserved. |
| WOS关键词 | SPINNING H-1-NMR SPECTROSCOPY ; NEPHRON-SPARING SURGERY ; NMR-SPECTROSCOPY ; BLOOD-PLASMA ; PATTERN-RECOGNITION ; LIVER ; RATS ; H-1 ; THIOACETAMIDE ; METABOLISM |
| 资助项目 | K.C. Wong Education Foundation of Hong Kong[20705037] ; China Postdoctoral Science Foundation[30571861] ; National Natural Science Foundation of China[30570352] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000259112800012 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272831]  |
| 专题 | 分析化学研究室 药物安全性评价中心 |
| 通讯作者 | Huang, Yiran |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Urol, Shanghai 200127, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Analyt Chem Lab, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Hongchang,Dong, Baijun,Liu, Xia,et al. Metabonomic profiling of renal cell carcinoma: High-resolution proton nuclear magnetic resonance spectroscopy of human serum with multivariate data analysis[J]. ANALYTICA CHIMICA ACTA,2008,624(2):269-277. |
| APA | Gao, Hongchang,Dong, Baijun,Liu, Xia,Xuan, Hanqing,Huang, Yiran,&Lin, Donghai.(2008).Metabonomic profiling of renal cell carcinoma: High-resolution proton nuclear magnetic resonance spectroscopy of human serum with multivariate data analysis.ANALYTICA CHIMICA ACTA,624(2),269-277. |
| MLA | Gao, Hongchang,et al."Metabonomic profiling of renal cell carcinoma: High-resolution proton nuclear magnetic resonance spectroscopy of human serum with multivariate data analysis".ANALYTICA CHIMICA ACTA 624.2(2008):269-277. |
入库方式： OAI收割
来源：上海药物研究所
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